A Randomized Controlled Trial Study Comparing Adnexal Surgery by vNOTES or Laparoscopy
NCT ID: NCT06964594
Last Updated: 2025-05-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
200 participants
INTERVENTIONAL
2025-10-01
2028-12-31
Brief Summary
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Women aged 18 and above with an indication for adnexal surgery for benign gynecological pathology or prophylactic reasons will be able to participate.
After surgery the participants will answer a questioner, twice a day in seven days, about postoperative pain and how many units of analgesics they used.
Adnexal surgery is one of the most common surgical procedures performed in women and can either be performed to treat pathology as ovarian cysts or prophylactically in case of hereditary genetic alterations.
A laparoscopic technique is currently considered as gold standard for adnexal procedures. The latest advancement in minimally invasive surgery is vNOTES (vaginal natural orifice transluminal endoscopy), in which the entrance to the abdomen is performed by an anterior or more commonly posterior colpotomy rather than via the abdominal wall. The NOTABLE trial was a RCT showing that vNOTES adnexectomy was non-inferior to laparoscopy for successful removal of benign adnexa without conversion (Baekelandt). vNOTES adnexectomy had shorter surgical time, less use of analgesics and lower self-assessed VAS scores the first week post-operatively. The aim with our study is to compare postoperative pain after vNOTES versus laparoscopic adnexal surgery.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Laparoscopic Adnexal surgery
vNOTES adnexal surgery
New minimalinvasive technique
Interventions
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vNOTES adnexal surgery
New minimalinvasive technique
Eligibility Criteria
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Inclusion Criteria
* Female aged 18 years or above.
* Diagnosed with adnexal pathology or subject for prophylactic BSO.
Exclusion Criteria
* Scheduled elective surgery or other procedures requiring general anaesthesia during the trial.
* Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participant at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial.
* Patients taking opioids or other painkillers routinely pre-operatively.
* Patients with chronic pelvic pain.
* Patients with surgical contraindication; previous hysterectomy, history of rectal surgery, suspected or confirmed endometriosis, suspected malignancy, suspected obliteration of the pouch of Douglas following severe PID or other causes, active lower genital tract infection, pregnancy.
* Failure to provide written informed consent prior to surgery
18 Years
FEMALE
No
Sponsors
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Region Skane
OTHER
Responsible Party
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Andrea Stuart
Associate Professor
Central Contacts
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Other Identifiers
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2025-00965-01
Identifier Type: -
Identifier Source: org_study_id
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