Evaluation of the Biomechanics of Crowding and the Energetic Cost of Endurance Runners Unilateral Transtibial Amputees.

NCT ID: NCT06948695

Last Updated: 2025-08-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-23

Study Completion Date

2026-11-01

Brief Summary

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Transtibial amputation accounts for 3,700 cases per year in France. Athletes can use sport blades made of carbon plate for improved energy restitution.

Sports blades are adjusted according to the manufacturer's recommendations and the subjective experience of the ortho-prosthetist and patient. These adjustments are designed to optimize performance and comfort while reducing the risk of injury. This risk is all the greater when asymmetries between the healthy and affected limbs are large, exposing the healthy limb to large and repeated reaction forces.

Detailed Description

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Furthermore, one of the performance criteria for long-distance running is energy cost. While a reduction in this parameter has been observed in bilateral amputees, heterogeneous data are reported in unilateral amputees, depending on the level of expertise and sports blade settings.

While studies have investigated the effects of running with a prosthesis under conditions representative of track running, few data are available on sports blades designed for long-distance running.

It therefore seems important to be able to objectively assess the effects of a change in the stiffness of the sports blade on the energetics and biomechanics of running, in order to optimize practice and prevent associated traumas.

Secondly, investigators believe it is important to verify that the biomechanical results obtained in the laboratory are applicable in the field, both on the road and on the unstable terrain encountered by trail runners.

Conditions

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Amputee Prostheses Healthy Volunteers

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

prospective randomized cross-over study
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Usual blade stiffness

Data collection on a blade with usual stiffness during a run at comfort speed according to slope (flat, uphill +10% and downhill -10% on treadmill) and type of terrain (road, path).

Group Type ACTIVE_COMPARATOR

Warm-up

Intervention Type OTHER

5-minute warm-up run on treadmill at a freely chosen speed

Random blade test

Intervention Type OTHER

4-minute run on a treadmill with a flat incline.

Random blade test

Intervention Type OTHER

4-minute run on treadmill with a 10% gradient

Comfort speed test

Intervention Type OTHER

1 min running test on an instrumented treadmill (Gaitway, H/P/Cosmos, Nußdorf, Germany) at comfort speed.

Outdoor random blade test

Intervention Type OTHER

100-metre outdoor run at a comfort speed

Less stiff blade

Data collection on a less stiff blade during a run at comfort speed according to slope (flat, uphill +10% and downhill -10% on treadmill) and type of terrain (road, path).

Group Type ACTIVE_COMPARATOR

Warm-up

Intervention Type OTHER

5-minute warm-up run on treadmill at a freely chosen speed

Random blade test

Intervention Type OTHER

4-minute run on a treadmill with a flat incline.

Random blade test

Intervention Type OTHER

4-minute run on treadmill with a 10% gradient

Comfort speed test

Intervention Type OTHER

1 min running test on an instrumented treadmill (Gaitway, H/P/Cosmos, Nußdorf, Germany) at comfort speed.

Outdoor random blade test

Intervention Type OTHER

100-metre outdoor run at a comfort speed

Stiffer blade

Data collection on a stiffer blade during a run at comfort speed according to slope (flat, uphill +10% and downhill -10% on treadmill) and type of terrain (road, path).

Group Type ACTIVE_COMPARATOR

Warm-up

Intervention Type OTHER

5-minute warm-up run on treadmill at a freely chosen speed

Random blade test

Intervention Type OTHER

4-minute run on a treadmill with a flat incline.

Random blade test

Intervention Type OTHER

4-minute run on treadmill with a 10% gradient

Comfort speed test

Intervention Type OTHER

1 min running test on an instrumented treadmill (Gaitway, H/P/Cosmos, Nußdorf, Germany) at comfort speed.

Outdoor random blade test

Intervention Type OTHER

100-metre outdoor run at a comfort speed

Interventions

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Warm-up

5-minute warm-up run on treadmill at a freely chosen speed

Intervention Type OTHER

Random blade test

4-minute run on a treadmill with a flat incline.

Intervention Type OTHER

Random blade test

4-minute run on treadmill with a 10% gradient

Intervention Type OTHER

Comfort speed test

1 min running test on an instrumented treadmill (Gaitway, H/P/Cosmos, Nußdorf, Germany) at comfort speed.

Intervention Type OTHER

Outdoor random blade test

100-metre outdoor run at a comfort speed

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male or female,
* Weighing less than 110 kg, in accordance with C-blade recommendations,
* Subjects who have undergone a unilateral transtibial amputation,
* Have been running with a sports blade for at least 3 months, over several sessions of at least 3 kilometers.
* Subjects who have signed a written consent form,
* Subjects affiliated or entitled to a social security scheme.

Exclusion Criteria

* Subjects whose amputation is due to complications related to diabetes or atherosclerosis.
* Subjects with chronic or central neurological pathologies
* Subjects with cardiovascular disorders
* Subjects with alcohol or drug dependency.
* Pregnant or breast-feeding women
* Subjects under court protection.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Centre Hospitalier Universitaire de Saint Etienne

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David HUPIN, MD-PhD

Role: PRINCIPAL_INVESTIGATOR

CHU SAINT-ETIENNE

Locations

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Centre Hospitalier Universitaire

Saint-Etienne, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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David HUPIN, MD-PhD

Role: CONTACT

(0)4 77 82 83 00 ext. +33

Léonard FEASSON, MD-PhD

Role: CONTACT

(0)4 77 82 83 00 ext. +33

Facility Contacts

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David HUPIN, MD-PhD

Role: primary

(0)4 77 82 83 00 ext. +33

Other Identifiers

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2024-A01795-42

Identifier Type: OTHER

Identifier Source: secondary_id

24CH148

Identifier Type: -

Identifier Source: org_study_id

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