PNF and BFR Affect on Pain, ROM & Functional Outcome in Post-op ACL
NCT ID: NCT06943079
Last Updated: 2025-04-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
48 participants
INTERVENTIONAL
2024-02-11
2025-01-10
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
High Intensity Resistance Training With and Without Blood Flow Restriction in ACL Reconstruction
NCT06131047
Effects of Progressive Resistance Exercises Among Athletes With Hamstring Deficit After ACL Reconstruction
NCT06846164
Low-Load Blood Flow Restriction Training vs Traditional Resistance Training Exercises Following ACLR Surgery
NCT06480032
Structured Rehabilitation Program for Patients With Total Knee Replacement
NCT04694625
Effects of Low-intensity Strength Training With Concomitant Blood Flow Restriction on Pain Perception in Patients With Anterior Cruciate Ligament Surgery
NCT06699264
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
A - Hold Relax technique with Blood Flow Restriction technique
Effects of Hold Relax technique with Blood Flow Restriction on functional outcome
Effect of Hold Relax technique with Blood Flow Restriction technique on functional outcome
Participants are randomly allocated to group A through computerised generated method. The both combine intervention is divided into 3 intervals and their results will be calculated on 0 week, 3rd, and 6th week. On every interval, pain through numeric pain rating scale, range of motion through goniometer, and functional disability through lower extremity functional scale will be measured. 2-3/week frequency of intervention will be applied on the participant.
B - Hold relax technique without blood Flow Restriction technique
Effect of Hold Relax technique without Blood flow restriction on functional outcomes
Effect of Hold Relax technique without Blood Flow Restriction technique on functional outcomes
Participants are randomly allocated to group B through computerised generated method. The intervention is divided into 3 intervals and their results will be calculated on 0 week, 3rd, and 6th week. On every interval, pain through numeric pain rating scale, range of motion through goniometer, and functional disability through lower extremity functional scale will be measured. 2-3/week frequency of intervention will be applied on the participant.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Effect of Hold Relax technique with Blood Flow Restriction technique on functional outcome
Participants are randomly allocated to group A through computerised generated method. The both combine intervention is divided into 3 intervals and their results will be calculated on 0 week, 3rd, and 6th week. On every interval, pain through numeric pain rating scale, range of motion through goniometer, and functional disability through lower extremity functional scale will be measured. 2-3/week frequency of intervention will be applied on the participant.
Effect of Hold Relax technique without Blood Flow Restriction technique on functional outcomes
Participants are randomly allocated to group B through computerised generated method. The intervention is divided into 3 intervals and their results will be calculated on 0 week, 3rd, and 6th week. On every interval, pain through numeric pain rating scale, range of motion through goniometer, and functional disability through lower extremity functional scale will be measured. 2-3/week frequency of intervention will be applied on the participant.
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Both gender male and female.
* Patient underwent arthroscopic ACL repair procedure.
* Patients in 6 weeks of rehabilitation phase.
* Grafts of hamstring muscle were used in repair.
* Max range achieved after post-op day 1.
* Low- moderate pain intensity.
Exclusion Criteria
* Any Post-OP active infectionous Patients.
* Any circulatory effects.
* DVT and pulmonary embolism.
* Loose Implant placement.
* Non co-operative Patient.
* Hyperasthetic Patient.
* Polytraumatic Post-OP Patient.
25 Years
45 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Riphah International University
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Humera Mubashar Senior Lecturer, MS-OMPT
Role: PRINCIPAL_INVESTIGATOR
Riphah International University
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Ghurki Trust and Teaching Hospital
Lahore, Punjab Province, Pakistan
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Binkley JM, Stratford PW, Lott SA, Riddle DL. The Lower Extremity Functional Scale (LEFS): scale development, measurement properties, and clinical application. North American Orthopaedic Rehabilitation Research Network. Phys Ther. 1999 Apr;79(4):371-83.
Chesworth BM, Culham E, Tata GE, Peat M. Validation of outcome measures in patients with patellofemoral syndrome. J Orthop Sports Phys Ther. 1989;10(8):302-8. doi: 10.2519/jospt.1989.10.8.302.
Kujala UM, Jaakkola LH, Koskinen SK, Taimela S, Hurme M, Nelimarkka O. Scoring of patellofemoral disorders. Arthroscopy. 1993;9(2):159-63. doi: 10.1016/s0749-8063(05)80366-4.
Irrgang JJ, Snyder-Mackler L, Wainner RS, Fu FH, Harner CD. Development of a patient-reported measure of function of the knee. J Bone Joint Surg Am. 1998 Aug;80(8):1132-45. doi: 10.2106/00004623-199808000-00006.
Martin DP, Engelberg R, Agel J, Swiontkowski MF. Comparison of the Musculoskeletal Function Assessment questionnaire with the Short Form-36, the Western Ontario and McMaster Universities Osteoarthritis Index, and the Sickness Impact Profile health-status measures. J Bone Joint Surg Am. 1997 Sep;79(9):1323-35. doi: 10.2106/00004623-199709000-00006.
McHorney CA, Tarlov AR. Individual-patient monitoring in clinical practice: are available health status surveys adequate? Qual Life Res. 1995 Aug;4(4):293-307. doi: 10.1007/BF01593882.
Nelson EC, Berwick DM. The measurement of health status in clinical practice. Med Care. 1989 Mar;27(3 Suppl):S77-90. doi: 10.1097/00005650-198903001-00007.
Al-Hadidi F, Bsisu I, AlRyalat SA, Al-Zu'bi B, Bsisu R, Hamdan M, Kanaan T, Yasin M, Samarah O. Association between mobile phone use and neck pain in university students: A cross-sectional study using numeric rating scale for evaluation of neck pain. PLoS One. 2019 May 20;14(5):e0217231. doi: 10.1371/journal.pone.0217231. eCollection 2019.
Bergh A, Lauridsen NG, Hesbach AL. Concurrent Validity of Equine Joint Range of Motion Measurement: A Novel Digital Goniometer versus Universal Goniometer. Animals (Basel). 2020 Dec 19;10(12):2436. doi: 10.3390/ani10122436.
Perez-de la Cruz S, de Leon OA, Mallada NP, Rodriguez AV. Validity and intra-examiner reliability of the Hawk goniometer versus the universal goniometer for the measurement of range of motion of the glenohumeral joint. Med Eng Phys. 2021 Mar;89:7-11. doi: 10.1016/j.medengphy.2021.01.005. Epub 2021 Jan 27.
Keil H, Beisemann N, Swartman B, Schnetzke M, Vetter SY, Grutzner PA, Franke J. Intraoperative revision rates due to three-dimensional imaging in orthopedic trauma surgery: results of a case series of 4721 patients. Eur J Trauma Emerg Surg. 2023 Feb;49(1):373-381. doi: 10.1007/s00068-022-02083-x. Epub 2022 Sep 1.
Dong HY, Tong MS, Wang J, Liu Y, Tao GY, Petersen RH, Jara-Palomares L, Wang Y, Sun YB, Chen J. Risk factors for pulmonary embolism in lung cancer patients with lower limb deep venous thrombosis: a case-control study. Transl Lung Cancer Res. 2023 Jul 31;12(7):1539-1548. doi: 10.21037/tlcr-23-346. Epub 2023 Jul 19.
Muller S, Buhl L, Nuesch C, Pagenstert G, Mundermann A, Egloff C. Favorable Patient-Reported, Clinical, and Functional Outcomes 2 Years After ACL Repair and InternalBrace Augmentation Compared With ACL Reconstruction and Healthy Controls. Am J Sports Med. 2023 Oct;51(12):3131-3141. doi: 10.1177/03635465231194784. Epub 2023 Sep 7.
Barman SR, Chan SW, Kao FC, Ho HY, Khan I, Pal A, Huang CC, Lin ZH. A self-powered multifunctional dressing for active infection prevention and accelerated wound healing. Sci Adv. 2023 Jan 25;9(4):eadc8758. doi: 10.1126/sciadv.adc8758. Epub 2023 Jan 25.
Rim CH, Park S, Yoon WS, Shin IS, Park HC. Radiotherapy for bone metastases of hepatocellular carcinoma: a hybrid systematic review with meta-analyses. Int J Radiat Biol. 2023;99(3):419-430. doi: 10.1080/09553002.2022.2094020. Epub 2022 Aug 8.
Ayres JM, Dallman J, Nolte JA, Higginbotham N, Baker J, Horton G, Salava J, Sojka J, Templeton KJ, Malancea RI, Heddings A. Managing Post-Operative Pain in Orthopedic Patients: An International Comparison. Kans J Med. 2023 Feb 21;16(1):56-60. doi: 10.17161/kjm.vol16.18744. eCollection 2023.
Helito CP, da Silva AGM, Sobrado MF, Guimaraes TM, Gobbi RG, Pecora JR. Small Hamstring Tendon Graft for Anterior Cruciate Ligament Reconstruction Combined With Anterolateral Ligament Reconstruction Results in the Same Failure Rate as Larger Hamstring Tendon Graft Reconstruction Alone. Arthroscopy. 2023 Jul;39(7):1671-1679. doi: 10.1016/j.arthro.2023.01.101. Epub 2023 Feb 10.
Kotsifaki R, Korakakis V, King E, Barbosa O, Maree D, Pantouveris M, Bjerregaard A, Luomajoki J, Wilhelmsen J, Whiteley R. Aspetar clinical practice guideline on rehabilitation after anterior cruciate ligament reconstruction. Br J Sports Med. 2023 May;57(9):500-514. doi: 10.1136/bjsports-2022-106158. Epub 2023 Feb 2.
Buckthorpe M, Gokeler A, Herrington L, Hughes M, Grassi A, Wadey R, Patterson S, Compagnin A, La Rosa G, Della Villa F. Optimising the Early-Stage Rehabilitation Process Post-ACL Reconstruction. Sports Med. 2024 Jan;54(1):49-72. doi: 10.1007/s40279-023-01934-w. Epub 2023 Oct 3.
Li S, Shaharudin S, Abdul Kadir MR. Effects of Blood Flow Restriction Training on Muscle Strength and Pain in Patients With Knee Injuries: A Meta-Analysis. Am J Phys Med Rehabil. 2021 Apr 1;100(4):337-344. doi: 10.1097/PHM.0000000000001567.
Korkmaz E, Donmez G, Uzuner K, Babayeva N, Torgutalp SS, Ozcakar L. Effects of Blood Flow Restriction Training on Muscle Strength and Architecture. J Strength Cond Res. 2022 May 1;36(5):1396-1403. doi: 10.1519/JSC.0000000000003612. Epub 2020 Apr 13. No abstract available.
Early KS, Rockhill M, Bryan A, Tyo B, Buuck D, McGinty J. EFFECT OF BLOOD FLOW RESTRICTION TRAINING ON MUSCULAR PERFORMANCE, PAIN AND VASCULAR FUNCTION. Int J Sports Phys Ther. 2020 Dec;15(6):892-900. doi: 10.26603/ijspt20200892.
Cayco CS, Labro AV, Gorgon EJR. Hold-relax and contract-relax stretching for hamstrings flexibility: A systematic review with meta-analysis. Phys Ther Sport. 2019 Jan;35:42-55. doi: 10.1016/j.ptsp.2018.11.001. Epub 2018 Nov 3.
Jack RA 2nd, Lambert BS, Hedt CA, Delgado D, Goble H, McCulloch PC. Blood Flow Restriction Therapy Preserves Lower Extremity Bone and Muscle Mass After ACL Reconstruction. Sports Health. 2023 May;15(3):361-371. doi: 10.1177/19417381221101006. Epub 2022 Jun 27.
Yuan J, Wu L, Xue Z, Xu G, Wu Y. Application and progress of blood flow restriction training in improving muscle mass and strength in the elderly. Front Physiol. 2023 Mar 24;14:1155314. doi: 10.3389/fphys.2023.1155314. eCollection 2023.
Jacobs E, Rolnick N, Wezenbeek E, Stroobant L, Capelleman R, Arnout N, Witvrouw E, Schuermans J. Investigating the autoregulation of applied blood flow restriction training pressures in healthy, physically active adults: an intervention study evaluating acute training responses and safety. Br J Sports Med. 2023 Jul;57(14):914-920. doi: 10.1136/bjsports-2022-106069. Epub 2023 Jan 5.
Colapietro M, Portnoff B, Miller SJ, Sebastianelli W, Vairo GL. Effects of Blood Flow Restriction Training on Clinical Outcomes for Patients With ACL Reconstruction: A Systematic Review. Sports Health. 2023 Mar-Apr;15(2):260-273. doi: 10.1177/19417381211070834. Epub 2022 Feb 8.
Labata-Lezaun N, Llurda-Almuzara L, Gonzalez-Rueda V, Lopez-de-Celis C, Cedeno-Bermudez S, Banuelos-Pago J, Perez-Bellmunt A. Effectiveness of Blood Flow Restriction Training on Muscle Strength and Physical Performance in Older Adults: A Systematic Review and Meta-analysis. Arch Phys Med Rehabil. 2022 Sep;103(9):1848-1857. doi: 10.1016/j.apmr.2021.12.015. Epub 2022 Jan 10.
Nishimura H, Yamaura K, Stetzelberger VM, Garcia AR, Hollenbeck JFM, Brown JR, Mologne MS, Uchida S, Philippon MJ. Biomechanical Comparison of Proximal Hamstring Reconstruction Using Distal Hamstring Graft Versus Fascia Lata Graft for Treatment of Chronic Hamstring Injury. Am J Sports Med. 2023 Dec;51(14):3756-3763. doi: 10.1177/03635465231206464. Epub 2023 Nov 17.
Minoli C, Travi M, Monti C, Ferrua P, Puce M, Radaelli S, Menon A, Tassi AL, Randelli PS. A fast, easy and reliable method for hamstrings graft size prediction in anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2023 Oct;31(10):4430-4436. doi: 10.1007/s00167-023-07510-z. Epub 2023 Jul 19.
Aagaard P, Simonsen EB, Andersen JL, Magnusson SP, Bojsen-Moller F, Dyhre-Poulsen P. Antagonist muscle coactivation during isokinetic knee extension. Scand J Med Sci Sports. 2000 Apr;10(2):58-67. doi: 10.1034/j.1600-0838.2000.010002058.x.
Gillquist J, Hagberg G, Oretorp N. Arthroscopy in acute injuries of the knee joint. Acta Orthop Scand. 1977;48(2):190-6. doi: 10.3109/17453677708985134.
Konda SR, Davidovitch RI, Egol KA. Open knee joint injuries--an evidence-based approach to management. Bull Hosp Jt Dis (2013). 2014;72(1):61-9.
KAPLAN EB. Some aspects of functional anatomy of the human knee joint. Clin Orthop. 1962;23:18-29. No abstract available.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
REC/RCR & AHS/24/0120
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.