Feasibility of ECG-Based Glucose Monitoring System

NCT ID: NCT06883682

Last Updated: 2025-03-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

165 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-02-10

Study Completion Date

2025-09-30

Brief Summary

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This is a single-center, open-label clinical trial to assess the feasibility of using ECG information in estimating glucose level continuously in adult subjects.

Detailed Description

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About 165 subjects distributed in 3 categories according to the risk of developing events of hyperglycemia or hypoglycemia will be enrolled. Subjects will wear a portable ECG recorder to monitor ECG information and use 3 blood glucose monitoring methods to monitor blood glucose level over time. All data will be pooled together to train a specific artificial intelligence (AI) algorithm to conduct a blood glucose detection model using ECG features. The trial period is about 21 days.

Conditions

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Diabetes Mellitus

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Monitoring arm

Subjects will wear a portable ECG recorder to monitor ECG information and use 3 blood glucose monitoring methods to monitor blood glucose level over time.

No intervention

Intervention Type OTHER

No intervention is conducted in this study.

Interventions

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No intervention

No intervention is conducted in this study.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Males and females, age 18 years or older.
* Subjects can communicate clearly, fully understand the informed consent form, and are aware of the rights and obligations of the study.
* Category 1: Subjects without a medical history of hyperglycemia / hypoglycemia or type 1 / type 2 diabetes.

Category 2: Subjects having diabetes mellitus (DM) and HbA1c value of. 5.5% to 10%, with eGFR ≥ 60 mL/min.

Category 3: Subjects having chronic kidney disease (CKD) and diabetes. mellitus (DM), with eGFR \< 60 mL/min.

• Willing and able to participate in all aspects of the study.

Exclusion Criteria

* Subjects suffering from insomnia or severe digestive system disorders within 3 months prior to the screening visit.
* Subjects who are addicted to alcohol or caffeine.
* Existing severe cardiac conditions such as recent myocardial infarction or advanced heart failure within 6 months prior to the screening visit.
* Has experienced an episode of confirmed or suspected diabetic ketoacidosis (DKA) within 6 months prior to the screening visit.
* Subjects who are vulnerable groups or with higher risks, such as HIV carriers, pregnant women or planning to become pregnant within the study duration, breast-feeding mothers, subjects with rare diseases, physical disabilities, incurable fatal diseases, dependents in nursing homes, incapacity, or intellectual or mental disabilities.
* Has a concomitant disease or condition that may compromise subject safety such as unstable coronary heart disease, cystic fibrosis, serious psychiatric disorder, or any other uncontrolled medical conditions.
* Any active infection or malignancy requiring acute therapy.
* Having coagulation disorders.
* Has known allergy to medical adhesives.
* Subjects using any cardiac related implantable medical devices such as a pacemaker and so on.
* Subjects on certain drugs known to cause arrhythmias or significantly impact kidney function or blood glucose levels (except for the current daily use medication).
* Subjects have used defibrillators within 3 months prior to the screening visit.
* Currently participating in another device or drug study.
* Currently receiving dialysis treatment or planning to receive dialysis during the study.
* Any other clinical condition that, in the investigator's judgment, would potentially compromise study compliance or the ability to evaluate safety/efficacy.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Landseed International Hospital

UNKNOWN

Sponsor Role collaborator

Singular Wings Medical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ying-Kuang Lin, M.D. Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Landseed International Hospital

Locations

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Landseed International Hospital

Taoyuan District, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Jasper Yang, Ph.D.

Role: CONTACT

886 3667 5801

Jesse Liao

Role: CONTACT

886 3667 5801

Facility Contacts

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Yi-Shu Chang

Role: primary

886-3494-1234

Other Identifiers

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SWM-BG-001

Identifier Type: -

Identifier Source: org_study_id

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