Impact of Aligner Replacement Protocols on Predictability of Planned Dental Movements: Evaluation of Double Aligner

NCT ID: NCT06882395

Last Updated: 2025-03-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

114 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-11-06

Study Completion Date

2027-07-31

Brief Summary

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The study will evaluate the impact of replacing aligners after 7 days with new aligners made of different materials on the predictability of planned dental movements. Three groups of participants will follow different aligner protocols, and the planned movements will be compared with the achieved ones. The study aims to provide relevant data for clinical practices with orthodontic aligners and assess participants' satisfaction with the treatment.

Detailed Description

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This prospective clinical trial aims to determine whether replacing an aligner after 7 days with a new aligner of a different material affects the predictability of planned dental movements. A total of 114 adult patients undergoing orthodontic treatment with aligners-requiring bilateral tooth movements (extrusion, intrusion, rotation, tipping, or mesiodistal translation)-will be recruited and randomized into three groups with distinct aligner exchange protocols.

Group 1: 10 days of exclusive FLX aligner use. Group 2: 7 days of FLX aligner use followed by 3 days of FLX35 use. Group 3: 7 days of FLX aligner use followed by 3 days of a new FLX aligner. Within each group, patients will be further categorized into subgroups based on horizontal, vertical, and rotational movements. Digital study models, radiographs, and standardized clinical photographs will be used to compare planned versus achieved tooth movements. The primary outcome is the predictability of movement, defined as the difference and percentage of planned versus actual movement. Secondary outcomes include participant satisfaction measured via the OHIP-14 questionnaire. Data will be analyzed using descriptive statistics and paired tests appropriate for the split-mouth design. The study is conducted in accordance with the Declaration of Helsinki, and all treatment costs will be covered by the sponsor, NeoDent (JJGC Industria e Comercio de Materiais Dentarios S.A.).

Conditions

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Malocclusion Clear Aligner Appliance Orthodontics Tooth Movement

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Arm 1: FLX aligner 10 days

Participants use the FLX aligner exclusively for 10 days.

Group Type ACTIVE_COMPARATOR

Group 1: FLX aligners for 10 days

Intervention Type DEVICE

FLX aligners worn for 10 days

Arm 2: FLX for 10 days + FLX35 for 3 days

Participants use the FLX aligner for 7 days, followed by the FLX35 aligner for 3 days.

Group Type EXPERIMENTAL

Group 2: FLX aligners worn for 7 days, followed by FLX35 aligners for 3 days.

Intervention Type DEVICE

Group 2: FLX aligners for 7 days, followed by FLX35 aligners for 3 days.

FLX aligner for 7 days + FLX for 3 days

FLX aligner for 7 days, followed by the FLX aligner for 3 days

Group Type EXPERIMENTAL

Group 3: FLX aligners for 7 days, followed by new FLX aligners for 3 days.

Intervention Type DEVICE

Group 3: FLX aligners worn for 7 days, followed by new FLX aligners for 3 days.

Interventions

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Group 1: FLX aligners for 10 days

FLX aligners worn for 10 days

Intervention Type DEVICE

Group 3: FLX aligners for 7 days, followed by new FLX aligners for 3 days.

Group 3: FLX aligners worn for 7 days, followed by new FLX aligners for 3 days.

Intervention Type DEVICE

Group 2: FLX aligners worn for 7 days, followed by FLX35 aligners for 3 days.

Group 2: FLX aligners for 7 days, followed by FLX35 aligners for 3 days.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Adults aged 18 years or older, with full permanent dentition.
* Interested in orthodontic treatment with aligners.
* Planned movements include extrusion, intrusion, rotation, tipping, or mesiodistal translation.
* Signed informed consent.

Exclusion Criteria

* Contraindications to aligner use, including allergies to polyurethane or PETG.
* Poor oral hygiene or active periodontal disease.
* Malocclusions involving multiple missing teeth or short clinical crowns.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Neodent

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Private orthodontic clinic

Curitba, Paraná, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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CC.2024.Double_Aligner

Identifier Type: -

Identifier Source: org_study_id

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