Effect of Acute Protein Supplementation in Diabetic Patients
NCT ID: NCT06880614
Last Updated: 2025-12-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2025-06-01
2025-12-01
Brief Summary
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Researcher will compare house cricket powder with placebo to see if the glycemic response is better in house cricket supplemented group.
Researcher will compare house cricket powder with whey protein isolate to see if both supplement induce comparable glycemic response.
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Detailed Description
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Baseline 20 minutes after pre load 15 minutes after Oral Glucose Tolerance Test (OGTT) 30 minutes after OGTT 45 minutes after OGTT 60 minutes after OGTT 90 minutes after OGTT 120 minutes after OGTT
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
TRIPLE
Study Groups
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Placebo
This arm will be given chicken-flavored soup without any supplements before conducting the oral glucose tolerance test
Oral Glucose Tolerance test (75g 2-hour)
The participants are required to drink a glucose solution containing 75 g of glucose dissolved in 250 mL of water
Placebo
Placebo consists of chicken-flavored soup without any supplement inside
Whey
This arm will be given chicken-flavored soup containing whey isolate powder before conducting the oral glucose tolerance test
Oral Glucose Tolerance test (75g 2-hour)
The participants are required to drink a glucose solution containing 75 g of glucose dissolved in 250 mL of water
Whey
Supplemented with whey protein isolate masked with a chicken-flavored soup
House Cricket
This arm will be given chicken-flavored soup containing house cricket powder before conducting the oral glucose tolerance test
Oral Glucose Tolerance test (75g 2-hour)
The participants are required to drink a glucose solution containing 75 g of glucose dissolved in 250 mL of water
House cricket
Supplemented with house cricket powder masked with chicken-flavored soup
Interventions
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Oral Glucose Tolerance test (75g 2-hour)
The participants are required to drink a glucose solution containing 75 g of glucose dissolved in 250 mL of water
Whey
Supplemented with whey protein isolate masked with a chicken-flavored soup
House cricket
Supplemented with house cricket powder masked with chicken-flavored soup
Placebo
Placebo consists of chicken-flavored soup without any supplement inside
Eligibility Criteria
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Inclusion Criteria
* Consume metformin for at least 6 months
Exclusion Criteria
* Presenting any food allergy
* Recent surgery or infections that may affect oral glucose tolerance test
* Consume other drugs that may affect oral glucose tolerance test
* Not consuming any anti-diabetic drugs
* Pre-diabetes (HbA1c 5.7 - 6.4%)
MALE
No
Sponsors
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University of Malaya
OTHER
Responsible Party
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JERRY VANLIN
Principal Investigator
Principal Investigators
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Ashril Yusof, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Malaya
Locations
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Queen Elizabeth Hospital Kota Kinabalu
Kota Kinabalu, Sabah, Malaysia
Countries
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References
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Clifton PM, Galbraith C, Coles L. Effect of a low dose whey/guar preload on glycemic control in people with type 2 diabetes--a randomised controlled trial. Nutr J. 2014 Oct 25;13:103. doi: 10.1186/1475-2891-13-103.
Oberoi A, Giezenaar C, Rigda RS, Horowitz M, Jones KL, Chapman I, Soenen S. Effects of co-ingesting glucose and whey protein on blood glucose, plasma insulin and glucagon concentrations, and gastric emptying, in older men with and without type 2 diabetes. Diabetes Obes Metab. 2023 May;25(5):1321-1330. doi: 10.1111/dom.14983. Epub 2023 Feb 22.
Jakubowicz D, Froy O, Ahren B, Boaz M, Landau Z, Bar-Dayan Y, Ganz T, Barnea M, Wainstein J. Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial. Diabetologia. 2014 Sep;57(9):1807-11. doi: 10.1007/s00125-014-3305-x. Epub 2014 Jul 10.
Dai J, Lov J, Martin-Arrowsmith PW, Gritsas A, Churchward-Venne TA. The acute effects of insect vs. beef-derived protein on postprandial plasma aminoacidemia, appetite hormones, appetite sensations, and energy intake in healthy young men. Eur J Clin Nutr. 2022 Nov;76(11):1548-1556. doi: 10.1038/s41430-022-01157-8. Epub 2022 May 10.
Kashima H, Uemoto S, Eguchi K, Endo MY, Miura A, Kobayashi T, Fukuba Y. Effect of soy protein isolate preload on postprandial glycemic control in healthy humans. Nutrition. 2016 Sep;32(9):965-9. doi: 10.1016/j.nut.2016.02.014. Epub 2016 Mar 8.
Other Identifiers
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LPK2203
Identifier Type: -
Identifier Source: org_study_id
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