Respiratory Oxygen Adherence Monitor for Chronic Obstructive Pulmonary Disease Patients

NCT ID: NCT06874101

Last Updated: 2025-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-01

Study Completion Date

2026-04-30

Brief Summary

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The goal of this clinical trial is to test a device called "ROAM" that is being developed to see how patients with chronic obstructive pulmonary disease (COPD) use oxygen therapy over a long period of time. This study will focus on evaluating the ROAM device, which will be attached to your oxygen source. The question that the study aims to answer is: will patients who receive daily adherence feedback from the ROAM have increased adherence to their prescribed long term oxygen therapy regimens?

Researchers will compare the amount of time using oxygen and attitudes about oxygen therapy observed in a group that receives feedback from ROAM, and a control group that does not receive feedback.

Participants will have their oxygen supplies fitted with the ROAM device and then use their oxygen as usual for the 5-week study duration. Participants in the study group will have access to information about their oxygen usage and pulse oximetry levels. All participants will attend two in-clinic sessions of about an hour each, and will complete questionnaires at the beginning and end of the study.

Detailed Description

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This clinical trial will be a conventional randomized, parallel controlled trial to evaluate the primary hypothesis that a 4-week period of using the ROAM adherence monitor and support system will result in increased adherence when compared to a control group with no adherence monitoring. The participant population will be individuals with chronic obstructive pulmonary disease (COPD), and who have been prescribed oxygen therapy for a minimum of 8 hours/day. Half of the participants will be randomly assigned to the ROAM group; the other half will comprise the control group.

All participants will bring their regular oxygen supplies to the clinic to be fitted with the ROAM sensors. To establish baseline adherence, for the first week, all participants will be blinded to feedback from the ROAM system (including oxygen usage times and oxygen saturation levels); a special code will disable feedback on the local system, including the adherence displays and notifications. After one week, the oxygen usage times will be averaged, and used as a baseline of adherence.

Control participants will continue to be blinded to the ROAM feedback for the next four weeks. After the first week, the ROAM group participants will be instructed to enter a code to enable the ROAM user feedback display on the concentrator and portable tank systems. These participants will be instructed to take pulse oximetry readings as they usually do using the ROAM system's included oximeter. A minimum of two readings per day will be encouraged by built-in alerts on the system. They will continue using the system, while receiving feedback on daily adherence rates and oxygen saturation levels, for the 4-week study duration.

The average daily oxygen use times over the four-week study period will be computed, and use times for the ROAM group will be compared to those of the control group. At the beginning and end of the study, patients will complete a questionnaire to assess attitudes toward treatment. The primary outcome metric will be adherence rates (% adherent = actual treatment time/prescribed treatment time) of the oxygen therapy. The secondary outcome metric will be attitude towards treatment, as assessed via questionnaires.

Conditions

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COPD COPD - Chronic Obstructive Pulmonary Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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ROAM Group

The ROAM group participants will have access to the ROAM user feedback display on their concentrator and portable tank oxygen delivery systems, throughout the 4-week study duration.

Group Type EXPERIMENTAL

Activated ROAM System with User Feedback

Intervention Type DEVICE

The activated ROAM device will provide the user with daily information about their oxygen therapy usage and pulse oximetry.

Control Group

The control group participants will have their oxygen delivery concentrators and portable tanks fitted with the ROAM system, which will monitor their usage, but they will not receive any of the user feedback or have access to the ROAM software.

Group Type SHAM_COMPARATOR

Sham Comparator

Intervention Type DEVICE

The sham comparator is a ROAM device that monitors oxygen usage, but keeps the usage details blind to the user.

Interventions

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Activated ROAM System with User Feedback

The activated ROAM device will provide the user with daily information about their oxygen therapy usage and pulse oximetry.

Intervention Type DEVICE

Sham Comparator

The sham comparator is a ROAM device that monitors oxygen usage, but keeps the usage details blind to the user.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Post-Bronchodilator FEV1/FVC\<.80
* Participants with medical history of COPD
* Prescription for oxygen use via nasal cannula or mask at home
* At baseline of health with no hospitalization/exacerbation within the past 6 weeks
* Use of Continuous oxygen at baseline

Exclusion Criteria

* Post -Bronchodilator FEV1/FVC ≤25%
* Intermittent oxygen use at home
* Inability to understand simple instructions
* Respiratory exacerbation or infections within 6 weeks prior to screen visit
* Not at baseline of medical health prior to screen visit
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Virginia

OTHER

Sponsor Role collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role collaborator

Barron Associates, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Eileen Krepkovich, MS

Role: PRINCIPAL_INVESTIGATOR

Barron Associates

Locations

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University of Virginia

Charlottesville, Virginia, United States

Site Status

Countries

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United States

Central Contacts

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Eileen Krepkovich, MS

Role: CONTACT

434-973-1215 ext. 123

Facility Contacts

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Yun Shim, MD

Role: primary

434-924-5219

Other Identifiers

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5R44HL147667-03

Identifier Type: NIH

Identifier Source: secondary_id

View Link

ROAM

Identifier Type: -

Identifier Source: org_study_id

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