Effects of Bidomain Cognitive and Aerobic Training on Cognitive Functioning in Mild Cognitive Impairment.

NCT ID: NCT06867016

Last Updated: 2025-03-10

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 44 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-02-28
• Study Completion Date: 2025-08-28

Brief Summary

The study aims to assess the effects of Bidomain cognitive and aerobic training on both cognitive functioning and quality of life in individuals with mild cognitive impairment.

Detailed Description

The proposed study addresses a notable gap in the literature regarding the comparison between combined cognitive-aerobic training and cognitive training alone in improving cognitive function for patients with mild cognitive impairment (MCI). While previous studies have demonstrated the positive effects of both training methods on cognitive function independently, there is currently no research directly comparing their effectiveness when used together. The study aims to provide evidence on which treatment regime-combined cognitive-aerobic training or cognitive training alone-offers better outcomes for MCI patients. Aerobic training is known to enhance brain structure and function by strengthening neuronal connections, largely due to increased levels of brain-derived neurotrophic factor (BDNF) and enhanced vascularization, which stimulates hippocampal growth. On the other hand, cognitive training improves global cerebral functional connectivity, particularly activating the prefrontal cortex, which leads to better cognitive performance. Combining these training modalities may yield greater benefits than focusing on just one, offering a cost-effective, accessible approach that could significantly improve the quality of life and daily functioning for individuals with MCI.

Conditions

Mild Cognitive Impairment

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Combined Cognitive & Aerobic Training Group

The ACT combined training will consist of simultaneous aerobic exercise and cognitive training in a dual-task format.

Group Type: EXPERIMENTAL

Combined Cognitive & Aerobics Training

Intervention Type: OTHER

The ACT combined training will consist of simultaneous aerobic exercise and cognitive training in a dual-task format, conducted twice a week for 8 weeks. The aerobic training (AT) will consist of twice-weekly sessions that include yoga, brisk walking, pedaling exercises, and step aerobics, alongside cognitive training involving speed processing, memory recall, problem-solving, and visual attention exercises. Each session will last approximately 20 minutes, and assessments will be performed at baseline, 4th week, and 8th week.

Cognitive Training Group

Cognitive training group include cognitive training involving speed processing, memory recall, problem-solving, and visual attention exercises.

Group Type: ACTIVE_COMPARATOR

Cognitive Training

Intervention Type: OTHER

Cognitive training involving speed processing, memory recall, problem-solving, and visual attention exercises. Each session will last approximately 20 minutes, and assessments will be performed at baseline, the 4th week, and the 8th week.

Interventions

Combined Cognitive & Aerobics Training

The ACT combined training will consist of simultaneous aerobic exercise and cognitive training in a dual-task format, conducted twice a week for 8 weeks. The aerobic training (AT) will consist of twice-weekly sessions that include yoga, brisk walking, pedaling exercises, and step aerobics, alongside cognitive training involving speed processing, memory recall, problem-solving, and visual attention exercises. Each session will last approximately 20 minutes, and assessments will be performed at baseline, 4th week, and 8th week.

Intervention Type: OTHER

Cognitive Training

Cognitive training involving speed processing, memory recall, problem-solving, and visual attention exercises. Each session will last approximately 20 minutes, and assessments will be performed at baseline, the 4th week, and the 8th week.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Older adults 60 years & above
• With normal vision and color perception
• Independent Individual capable of carrying out daily tasks
• Individuals scoring 21-25 on the Mini-Mental State Examination (MMSE)

Exclusion Criteria

• Medication affecting the exercise capacity of individual
• Regular participation in aerobic training for the last six months
• Cardiovascular or other diseases that do not allow physical activity
• A diagnosed severe psychiatric disease (e.g., depression)
• Patients with cognitive impairment or other neurological impairments due to AD or dementia.

• Minimum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Riphah International University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Saliha Ashfaq, MS-NMPT*

Role: PRINCIPAL_INVESTIGATOR

Riphah International University

Locations

DHQ Chakwal

Chakwal, Punjab Province, Pakistan

Site Status: RECRUITING

Countries

Pakistan

Central Contacts

Abrish Habib Abbasi, MS-NMPT,Phd*

Role: CONTACT

abrish.habib@riphah.edu.pk

923155311799

Facility Contacts

Saliha Ashfaq, MS-NMPT*

Role: primary

salihaashfaq5121416@gmail.com

92335 0556968

Other Identifiers

REC/MS-PT/O2029 Saliha Ashfaq

Identifier Type: -

Identifier Source: org_study_id