Effect of Probiotic's Consumption on Several Markers in Perforated Appendix Patients with Diffuse Peritonitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

EARLY_PHASE1

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-01

Study Completion Date

2026-09-01

Brief Summary

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Does the administration of the probiotic Lactobacillus plantarum sp. have an impact on reducing leukocyte levels, segmented neutrophil counts, postoperative pain, and length of hospitalization in patients with diffuse peritonitis caused by perforated acute appendicitis who underwent laparotomy appendectomy at Dr. Hasan Sadikin Hospital?

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Detailed Description

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To determine whether the administration of the probiotic Lactobacillus plantarum sp. to patients with diffuse peritonitis caused by appendiceal perforation undergoing laparotomy appendectomy at Hasan Sadikin Hospital Bandung and Siloam Karawaci Hospital has a significant effect on leukocyte levels, segmented neutrophil counts, postoperative pain levels, and length of hospitalization compared to the placebo group.

Conditions

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Appendicitis with Perforation Appendectomy Probiotic

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Probiotic Group

Patient with perforated appendicitis who received an intervention

Group Type EXPERIMENTAL

Lactobacillus plantarum sp Probiotic

Intervention Type DIETARY_SUPPLEMENT

Once daily consumption

Placebo Group

Patients with perforated appendicitis who did not receive an intervention

Group Type PLACEBO_COMPARATOR

Placebo Group

Intervention Type OTHER

Group who received a placebo intervention

Interventions

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Lactobacillus plantarum sp Probiotic

Once daily consumption

Intervention Type DIETARY_SUPPLEMENT

Placebo Group

Group who received a placebo intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with diffuse peritonitis caused by appendicitis
* Patients undergoing laparotomic appendectomy.
* Patients aged 18 years or older.

Exclusion Criteria

* Patients with a history of previous laparotomy.
* Patients who underwent laparotomy combined with surgery on other parts of the body.
* Patients with a history of cancer.
* Patients with pre-existing comorbidities (uncontrolled diabetes mellitus, congestive heart failure, end-stage renal disease \[ESRD\], human immunodeficiency virus \[HIV\], and systemic lupus erythematosus \[SLE\]).
* Patients with multiple organ dysfunction syndrome (MODS).
* Patients with prior consumption of probiotics.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No