Treatment of Sleep Apnea to Improve Metabolic Health

NCT ID: NCT06848647

Last Updated: 2025-02-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-05-13

Study Completion Date

2028-12-31

Brief Summary

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Diabetes and prediabetes prevail among obstructive sleep apnea (OSA) patients. OSA and short sleep both detrimentally affect glycemic control regardless of obesity. With 1 in 10 adults having diabetes, 1 in 10 with prediabetes, and an estimated 600,000 affected by OSA in Sweden, attaining glycemic control is crucial. Though continuous positive airway pressure (CPAP) is the most effective treatment for OSA, its application lacks personalization, ignoring factors like comorbidities and sleep duration. Key unanswered questions regarding CPAP's impact on glycemic control include: 1) Does high CPAP adherence optimize glycemic control? 2) Should short sleep be addressed alongside OSA treatment for glycemic control? 3) Does long-term diabetes hinder CPAP's glycemic control efficacy? The purpose of this project is to enable precision health in CPAP treatment and producing a personalized treatment model for achieving glycemic control in patients with OSA, treated with CPAP. Taking advantage of a large unique patient cohort (600 patients followed over 18 months) with extensive and objective measures on CPAP adherence, OSA reduction, sleep duration, as well as information on comorbidities, anthropometric, lifestyle data, and a wide range of biomarkers related to glycemic control. This comprehensive approach and in-depth analysis will address these questions and generate a personalized treatment strategy for glycemic control in CPAP-treated OSA patients.

Detailed Description

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Conditions

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Sleep Apnea, Obstructive Metabolism CPAP Patients Above 18 Years

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with obstructive sleep apnea
* Planned for CPAP treatment
* 18 years and above

Exclusion Criteria

* Patient not wanting to participate in study
* Non-Swedish speaking
* Judged by physician as non-fit for study participation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Uppsala University Hospital

OTHER

Sponsor Role collaborator

Uppsala University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Uppsala University

Uppsala, Uppsala County, Sweden

Site Status RECRUITING

Countries

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Sweden

Central Contacts

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Jenny Theorell-Haglow, A.Prof, PhD

Role: CONTACT

+46 18 6110242

Other Identifiers

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20230298

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

2023-01150-01; 2023-05223-02

Identifier Type: -

Identifier Source: org_study_id

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