Obstructive Sleep Apnea and Diabetic Macular Edema Inflammatory Mediators

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2020-12-31

Brief Summary

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Obstructive sleep apnea (OSA) is characterized by intermittent nocturnal hypoxemia, frequent arousals, fragmented sleep and daytime sleepiness. It has been shown to increase the risk of cardiac and vascular disease through multiple mechanisms including sympathetic hyperactivity, metabolic dysregulation, and activation of oxidative stress and inflammatory pathways.

Diabetic retinopathy is a leading cause of blindness in the working age group, affecting 93 million people worldwide. Diabetic macular edema (DME) is a sight threatening complication and the most common cause of visual loss in patients with diabetes. OSA is frequently associated with diabetes with prevalence ranging from 23 to 86%. However, the relationship between OSA and DME is not well defined. The retina is especially susceptible to hypoxia, being one of the most metabolically active tissues. Many of the same inflammatory mediators have also been found to be elevated in patients with diabetic macular edema, including VEGF, VCAM-1 and IL-6.

There has been no previous study examining the biochemical impact of OSA on patients with DME. We aim to explore this relationship by examining the differences in inflammatory markers expressed in patients with DME who have undergone an overnight sleep study, which is considered the gold standard diagnostic tool in OSA.

Detailed Description

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The purpose of this study is to compare the levels of inflammatory mediators in diabetic patients with macular edema with and without OSA.

This will be a single centre, prospective, cross-sectional study. We will be recruiting patients undergoing intravitreal injection for diabetic macular edema divided into 2 groups:

* Group 1: diabetic patients with macular edema, no OSA
* Group 2: diabetic patients with macular edema, and OSA

All patients will undergo baseline ophthalmologic examination as part of a regular clinic visit including best-corrected visual acuity, intraocular pressure, slit lamp exam, dilated retinal exam, fluorescein angiography and optical coherence tomography (OCT). Diagnosis of diabetic macular edema will be confirmed with standard domain OCT. Diagnosis of OSA will be confirmed through gold standard of overnight polysomnography.

Data including demographics, ocular history, best corrected visual acuity, IOP, blood sugar control and sleep metrics will be collected. Serum and aqueous fluid samples will be collected at time of first intravitreal injection including VEGF, Placental growth factor, TGFB, ICAM-1,IL-2, IL-3, IL-6, IL-8, IL-10,IL-17, VCAM-1, MCP-1, Epidermal growth factor, Pigment epithelial derived factor (PEDF), Angiotensin 2 and Platelet derived growth factor (PDGF).

Primary outcome:

Levels of cytokine in serum and aqueous humour

Secondary outcome:

Best-corrected visual acuity

Data analysis:

Level of cytokines in serum and aqueous humor in patients with and without OSA will be compared using T test. Statistical significance is defined as p \< 0.05.

Conditions

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Diabetic Macular Edema Obstructive Sleep Apnea Diabetic Retinopathy

Keywords

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diabetic macular edema obstructive sleep apnea

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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OSA + DME +

Patients with OSA and DME

No interventions assigned to this group

OSA - DME +

Patients with DME, but no evidence of OSA

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Type I/II diabetic patients with evidence of diabetic macular edema requiring treatment with anti-VEGF

Exclusion Criteria

* Contraindications to intravitreal injection including stroke within the past month, ocular or peri-ocular infection, active intraocular inflammation, hypersensitivity to components of the intra-vitreal injection
* Any other retinal or macular pathology such as retinal detachment and age related macular degeneration
* Patients that have taken any systemic immunosuppressive or anti-inflammatory within the past 30 days
* Impaired mental capacity to comply (eg. dementia)
* Pregnant or breastfeeding women

Minimum Eligible Age

18 Years

Eligible Sex

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Locations

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Uptown Eye Speicialists

Brampton, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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OSA-DME 2

Identifier Type: -

Identifier Source: org_study_id