Effects of Continuous Positive Airway Pressure (CPAP) Treatment on Glucose Control in Patients With Type 2 Diabetes
NCT ID: NCT01136785
Last Updated: 2017-04-10
Study Results
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View full resultsBasic Information
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COMPLETED
NA
22 participants
INTERVENTIONAL
2009-11-30
2015-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Active CPAP therapy
7 days of treatment in the laboratory with active CPAP therapy.
active CPAP Therapy
7 days of active CPAP therapy
Sham CPAP therapy
7 days of sham CPAP therapy in the laboratory.
sham CPAP therapy
7 days of sham CPAP therapy
Interventions
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active CPAP Therapy
7 days of active CPAP therapy
sham CPAP therapy
7 days of sham CPAP therapy
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Subjects with unstable cardiopulmonary disease, painful neuropathy, significant psychiatric illness, cognitive impairment and pregnancy will be excluded.
* Shift workers
* Subjects having traveled across \>2 time zones less than one month prior to the study
* Diagnosis of a sleep disorder other than OSA by screening polysomnography
* Previous treatment with positive airway pressure or supplemental oxygen
* Requirement of supplemental oxygen or bi-level positive airway pressure for OSA treatment during titration
* Claustrophobia or other conditions of CPAP intolerance,
* Presence of active infection.
18 Years
ALL
No
Sponsors
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University of Chicago
OTHER
Responsible Party
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Principal Investigators
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Eve Van Cauter, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Chicago
Babak Mokhlesi, MD
Role: PRINCIPAL_INVESTIGATOR
University of Chicago
Locations
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The University of Chicago
Chicago, Illinois, United States
Countries
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References
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Mokhlesi B, Grimaldi D, Beccuti G, Van Cauter E. Effect of one week of CPAP treatment of obstructive sleep apnoea on 24-hour profiles of glucose, insulin and counter-regulatory hormones in type 2 diabetes. Diabetes Obes Metab. 2017 Mar;19(3):452-456. doi: 10.1111/dom.12823. Epub 2016 Dec 12.
Mokhlesi B, Grimaldi D, Beccuti G, Abraham V, Whitmore H, Delebecque F, Van Cauter E. Effect of One Week of 8-Hour Nightly Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea on Glycemic Control in Type 2 Diabetes: A Proof-of-Concept Study. Am J Respir Crit Care Med. 2016 Aug 15;194(4):516-9. doi: 10.1164/rccm.201602-0396LE. No abstract available.
Other Identifiers
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14-0547
Identifier Type: -
Identifier Source: org_study_id
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