Postoperative Delirium After Intraoperative Ephedrine Versus Norepinephrine
NCT ID: NCT06844201
Last Updated: 2025-02-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
10000 participants
OBSERVATIONAL
2025-02-20
2025-08-01
Brief Summary
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Detailed Description
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Propensity score matching through TriNetX will be used to adjust for age, sex, race, BMI, and comorbidities including cerebrovascular disease (ICD-10 code I60-I69), chronic heart failure (I11.0), primary hypertension (I10, I11.9), chronic obstructive pulmonary disease (COPD) (J42, J43, J44, J47), asthma (J45), chronic kidney disease (CKD) (I12, I13), diabetes mellitus (E08-E13), depression (F32.A), schizoaffective disorders (F25), alcohol and drug abuse (F10.1, F10.2, Z71.4), smoking status (F17.2, F17.21), and history of antipsychotic (CN700) and benzodiazepine (C302) usage.
Independent t-tests and chi-squared tests will be used to compare postoperative delirium across the cohorts. To evaluate the relationship between norepinephrine and postoperative delirium versus ephedrine and postoperative delirium, risk differences, and risk ratios with 95% CIs will be calculated following propensity score matching. The TriNetX platform will be used for all analyses, with p \< 0.05 representing statistical significance.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Ephedrine group
This group received ephedrine on the day of surgery.
Ephedrine
Received ephedrine the same day of surgery.
Norepinephrine group
This group received norepinephrine on the day of surgery.
Norepinephrine
Received norepinephrine the same day of surgery.
Interventions
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Ephedrine
Received ephedrine the same day of surgery.
Norepinephrine
Received norepinephrine the same day of surgery.
Eligibility Criteria
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Inclusion Criteria
* administered ephedrine on the day of surgery
* underwent surgery (CPT code 1003143)
* administered norepinephrine on the day of surgery
Exclusion Criteria
* patients who underwent neurology and neuromuscular surgery, cardiac surgery, and cardiac procedures
* patients who were administered epinephrine or dopamine on the day of surgery
* patients who were administered ephedrine or norepinephrine at any time within the 7 days following the day of surgery
* a prior history of disorientation (ICD-10 code R41.0) or unspecified dementia (F03)
Norepinephrine group:
* received both vasopressors (ephedrine and norepinephrine) on the day of surgery.
* patients who underwent neurology and neuromuscular surgery, cardiac surgery, and cardiac procedures
* patients who were administered epinephrine or dopamine on the day of surgery
* patients who were administered ephedrine or norepinephrine at any time within the 7 days following the day of surgery
* a prior history of disorientation (ICD-10 code R41.0) or unspecified dementia (F03)
ALL
No
Sponsors
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Riverside University Health System Medical Center
OTHER
Responsible Party
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Christopher Baker
Research Coordinator
Other Identifiers
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Ephedrine vs Norepinephrine
Identifier Type: -
Identifier Source: org_study_id
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