Follicular Volume at the Time of Final Oocyte Maturation in Poor Responders, and Its Correlation With Oocyte Maturity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-03-27

Study Completion Date

2025-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Women with a severely diminished ovarian reserve and monofollicular growth are at a higher risk of premature ovulation as well as poor quality oocytes. Our group showed previously that women with severely diminished ovarian reserve benefit from receiving the final oocyte maturation at smaller follicle sizes in terms of reducing the risk of premature ovulation and finding mature oocytes even out of small size follicles.

Adding the measurement of the follicular volume at the time of final oocyte maturation might provide more information on the proper timing of trigger administration compared to the follicular size alone, hormonal profile as well as previous stimulation attempts. Setting a cutoff value of follicular volume for trigger might help to avoid premature ovulation and possibly increase the chances of ending up with a euploid embryo.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Biomarkers of Ovarian Reserve and Correlation With IVF Treatments

NCT02442895

Pregnancy, Ovarian

COMPLETED

DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT

NCT05847283

Diminished Ovarian Reserve

RECRUITING NA

Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?

NCT05969574

Infertility, Female Miscarriage Miscarriage, Recurrent +1 more

RECRUITING

Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?

NCT04390308

Infertility, Female Premature Ovarian Failure IVF

RECRUITING

Accuracy of Ultrasound Markers Versus Biochemical Markers in Prediction of Ovarian Response in Obese Women Undergoing IVF/ICSI Treatment

NCT03684824

Invitro Fertilization

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

OVARIAN STIMULATION

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

The study population is the infertile patients seeking IVF treatment in ART fertility clinics of Abu

Recruited patients will be stimulated in a antagonist protocol with the use of Pergoveris as gonadotropin with a starting dose of 450 IU. The antagonist will be started on day 5 of the stimulation. Patients will be triggered according to clinical standard protocol for poor ovarian reserve patients when the leading follicle reaches 15 mm (2). The only additional measure will be the measurement of the follicle volumes on the day of trigger and before oocyte pick up procedure. This will be performed at the same time as the pre oocyte pick up ultrasound prior to the patient admission to the recovery room for preparation. The ultrasound that will be used already has a pre build program that calculates the follicular volume automatically and hence not extending the ultrasound time. Oocyte pickup will be performed the same way as per the SOP of the clinic for the patients who have less than 7 follicles on the day of the ovum pickup i.e. each follicle will be punctured, aspirated and then flu

transvaginal Ultrasound

Intervention Type OTHER

The only additional measure will be the measurement of the follicle volumes on the day of trigger and before oocyte pick up procedure. This will be performed at the same time as the pre Oocyte pick up ultrasound prior to the patient admission to the recovery room for preparation. The ultrasound that will be used already has a pre build program that calculates the follicular volume automatically and hence not extending the ultrasound time.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

transvaginal Ultrasound

The only additional measure will be the measurement of the follicle volumes on the day of trigger and before oocyte pick up procedure. This will be performed at the same time as the pre Oocyte pick up ultrasound prior to the patient admission to the recovery room for preparation. The ultrasound that will be used already has a pre build program that calculates the follicular volume automatically and hence not extending the ultrasound time.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Reproductive age group: 18 -48
* undergoing ovarian stimulation for oocyte vetrification
* undergoing IVF/ ICSI with PGT-A / PGT-M / PGT- Sr
* less than or equal to 3 AFC on initiation of stimulation
* follicular phase stimulation