Effect of Follicle Flushing on Oocyte Fertilization Rate
NCT ID: NCT03353285
Last Updated: 2018-01-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
60 participants
OBSERVATIONAL
2017-11-27
2018-06-01
Brief Summary
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Detailed Description
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Oocytes from each woman will be allocated to one of three groups, depending on the aspirate or flush they are recovered from:
Group I= egg retrieved in the follicular fluid of the first aspirate (no flushing) Group II= egg retrieved in the 1st-2nd flush Group III= egg retrieved in the 3rd-5th flush
development and utilization. Pregnancy rates will be reported as a surrogate outcome.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Group I
Group I= egg retrieved in the follicular fluid of the first aspirate (no flushing)
intracytoplasmic sperm injection (ICSI)
All eggs will be fertilized by ICSI
Group II
Group II= egg retrieved in the 1st-2nd flush
intracytoplasmic sperm injection (ICSI)
All eggs will be fertilized by ICSI
Group III
Group III= egg retrieved in the 3rd-5th flush
intracytoplasmic sperm injection (ICSI)
All eggs will be fertilized by ICSI
Interventions
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intracytoplasmic sperm injection (ICSI)
All eggs will be fertilized by ICSI
Eligibility Criteria
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Inclusion Criteria
* Both ovaries present
* Triggering final oocyte maturation using hCG or GnRH agonist
Exclusion Criteria
* PGD cases
18 Years
40 Years
FEMALE
No
Sponsors
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Eugonia
OTHER
Responsible Party
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Principal Investigators
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Tryfon G Lainas, Phd
Role: STUDY_DIRECTOR
Eugonia
Locations
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Eugonia
Athens, , Greece
Countries
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Central Contacts
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Facility Contacts
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References
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von Horn K, Depenbusch M, Schultze-Mosgau A, Griesinger G. Randomized, open trial comparing a modified double-lumen needle follicular flushing system with a single-lumen aspiration needle in IVF patients with poor ovarian response. Hum Reprod. 2017 Apr 1;32(4):832-835. doi: 10.1093/humrep/dex019.
Franasiak JM. Follicular flushing: time to look elsewhere to improve in vitro fertilisation outcomes? BJOG. 2017 Jul;124(8):1197. doi: 10.1111/1471-0528.14628. No abstract available.
Roque M, Sampaio M, Geber S. Follicular flushing during oocyte retrieval: a systematic review and meta-analysis. J Assist Reprod Genet. 2012 Nov;29(11):1249-54. doi: 10.1007/s10815-012-9869-9. Epub 2012 Oct 13.
Other Identifiers
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number of flushes
Identifier Type: -
Identifier Source: org_study_id
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