Chlorhexidine Versus N-Asetil Sistein Irrigation in Mandibular Molar Teeth with Chronic Apical Periodontitis
NCT ID: NCT06834711
Last Updated: 2025-02-20
Study Results
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Basic Information
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COMPLETED
NA
78 participants
INTERVENTIONAL
2024-02-15
2025-01-05
Brief Summary
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\- Does controlled irrigation with chlorhexidin and N-asetil sistein in root canal treatment reduce the severity of postoperative pain? In the chlorhexidin group, unlike the control group, each root canal was irrigated with 3 mL %2 chlorhexidin solution in the final irrigation.
In the N-asetil sistein group, unlike the control group, each root canal was irrigated with 3 mL 200 mg/ml N-asetil sistein solution in the final irrigation.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Control Group
During root canal preparation, each canal was irrigated with a total of 18 ml of 2.5% sodium hypochlorite (NaOCl). In the final irrigation, each root canal was irrigated with 3 ml of 17% ethylene diamine tetra-acetic acid (EDTA) for 1 minute, followed by 5 ml of distilled water. Then, 5 ml of 2.5% NaOCl was irrigated, and finally 5 ml of distilled water was used.
No interventions assigned to this group
Chlorhexidine Group
During root canal preparation, each canal was irrigated with a total of 18 ml of 2.5% NaOCl. In the final irrigation, each root canal was irrigated with 3 ml of 17% ethylene diamine tetra-acetic acid (EDTA) for 1 minute, followed by 5 ml of distilled water. Then, each canal was irrigated with 3 ml of 2% chlorhexidine (CHX) and finally 5 ml of distilled water was used.
Chlorhexidine
The root canals were irrigated with 3 ml %2 chlorhexidine in chlorhexidin group in the final irrigation.
N-asetil Sistein Group
During root canal preparation, each canal was irrigated with a total of 18 ml of 2.5% NaOCl. In the final irrigation, each root canal was irrigated with 3 ml of 17% ethylene diamine tetra-acetic acid (EDTA) for 1 minute, followed by 5 ml of distilled water. Then, each canal was irrigated with 3 ml of N-acetyl Cysteine (NAC) (200 mg/ml) and finally 5 ml of distilled water was used.
N-Acetyl Cysteine
The root canals were irrigated with 3 mL N-acetyl Cysteine (NAC)(200 mg/ml) in N-acetyl Cysteine group in the final irrigation.
Interventions
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N-Acetyl Cysteine
The root canals were irrigated with 3 mL N-acetyl Cysteine (NAC)(200 mg/ml) in N-acetyl Cysteine group in the final irrigation.
Chlorhexidine
The root canals were irrigated with 3 ml %2 chlorhexidine in chlorhexidin group in the final irrigation.
Eligibility Criteria
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Inclusion Criteria
* Teeth with periapical index (PAI) score greater than 2
* Teeth with periodontal pocket depth less than 3 mm
* Patients without systemic disease (ASA 1-2)
Exclusion Criteria
* Patients who report pregnancy, lactation or psychiatric disorders
* Teeth with a history of root canal treatment, sinus tract or abscess, and teeth planned for prosthetic restoration
18 Years
55 Years
ALL
No
Sponsors
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Cukurova University
OTHER
Responsible Party
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Kübra Gürler
Cukurova University, Faculty of Dentistry
Locations
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Cukurova University
Adana, Sarıçam, Turkey (Türkiye)
Countries
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References
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Corazza BJM, Martinho FC, Khoury RD, Toia CC, Orozco EIF, Prado RF, Machado FP, Valera MC. Clinical influence of calcium hydroxide and N-acetylcysteine on the levels of resolvins E1 and D2 in apical periodontitis. Int Endod J. 2021 Jan;54(1):61-73. doi: 10.1111/iej.13403. Epub 2020 Oct 3.
Comparative evaluation of N-acetylcysteine and chlorhexidine as final irrigation on the push-out bond strength of different sealers: An in vitro study
Other Identifiers
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13.02.2025/152
Identifier Type: -
Identifier Source: org_study_id
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