Comparison of Stent-Related Symptoms: Regular Double J Stent vs. Comfi J Stent

NCT ID: NCT06830902

Last Updated: 2025-02-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-02-15

Study Completion Date

2025-09-15

Brief Summary

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A prospective, single-blinded, randomized controlled trial conducted at a single center to compare stent related symptoms between two different stents using Ureteral Stent Symptom Questionnaire (USSQ) scores , Visual Analog Scale (VAS) pain scores.

Detailed Description

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Ureteral stents are widely used in urology following retrograde intrarenal surgeries and ureteric lithotripsy and other endourological procedures. However, their use is associated with significant discomfort, infections, and reduced quality of life (QoL). Over time, different materials and designs have been developed to improve stent performance and reduce complications. This study aims to compare the stent-related symptoms (SRS) of two types of ureteral stents: the regular Double J stent and the Comfi J stent.

Objectives of the study-

1. Compare Ureteral Stent Symptom Questionnaire (USSQ) scores between the two stents.
2. Compare Visual Analog Scale (VAS) pain scores.
3. Assess complications associated with each stent.
4. Evaluate the difficulty of stent insertion.

Study Design \& Methods: A prospective, single-blinded, randomized controlled trial conducted at a single center. Sample Size: 100 patients undergoing retrograde intrarenal surgery, ureteroscopic lithotripsy

Randomization: Intraoperative, using a computer-generated sequence, block randomization Assessments: USSQ and VAS scores at post-operative days (POD) 1, 7, and 14.

Statistical Analysis: Statistical Package for the Social Sciences software with a significance threshold of p \< 0.05.

Expected Outcomes: Determining whether the Comfi J stent reduces pain, urinary symptoms, and other complications compared to the regular Double J stent.

Evaluating if changes in design/material can improve patient QoL.

Ethical Considerations:

Institutional ethics approval and informed consent from all participants. Confidentiality ensured, with voluntary participation.

This study aims to provide evidence-based recommendations for improving ureteral stent tolerability and reducing patient morbidity

Conditions

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Stent Related Symptoms

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Single Blind, Randomised controlled trial
Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Regular Double J stent

Regular Double J stent placement

Group Type ACTIVE_COMPARATOR

Regular Double J stent

Intervention Type DEVICE

Regular Double J stent

Comfi J stent

Comfi J stent placement

Group Type ACTIVE_COMPARATOR

Comfi J stent

Intervention Type DEVICE

Comfi J stent

Interventions

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Regular Double J stent

Regular Double J stent

Intervention Type DEVICE

Comfi J stent

Comfi J stent

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Eligible participants were adult patients (aged 18-80 years) who underwent unilateral retrograde ureteroscopy (URS) lithotripsy for stone disease
* Retrograde intrarenal surgery (RIRS) lithotripsy with planned ureteric stent insertion for urinary tract stones

Exclusion Criteria

* Concomitant use of a-blockers, anticholinergics, corticosteroids, calcium channel blockers, and analgesics
* Undergoing percutaneous nephrolithotomy, open ureteric surgery or laparoscopic ureteric surgery, including ureterolithotomy
* Neurogenic bladder, Overactive bladder syndrome, and neurological and psychiatric diseases
* Preoperative febrile Urinary Tract Infection (UTI)
* Pregnancy or breastfeeding;
* A single kidney
* Moderate or severe cardiovascular or cerebrovascular disease
* Hepatic dysfunction
* History of pelvic surgery or irradiation
* History of bladder or prostate surgery
* Other acute medical conditions (including acute pancreatitis, acute gastroenteritis, musculoskeletal disorders) that might influence the USSQ pain score
* Allergy to any medication
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nepal Health Research Council

OTHER_GOV

Sponsor Role collaborator

Bir Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Anil Shrestha

Professor Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Bir Hospital

Kathmandu, Bagmati, Nepal

Site Status

Countries

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Nepal

Central Contacts

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Anil Shrestha, M Ch Urology

Role: CONTACT

009779851092274

Udita Mishra, M Ch Urology

Role: CONTACT

009779841389895

Facility Contacts

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Anil Shrestha, M Ch Urology

Role: primary

009779851092274

Udita Mishra, M Ch Urology

Role: backup

009779841389895

Other Identifiers

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ComfiJ

Identifier Type: -

Identifier Source: org_study_id

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