Risk Factors of Failure of Conservative Treatment in Acute Non Complicated Appendicitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-22

Study Completion Date

2025-12-02

Brief Summary

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From this study, it can be concluded that patients who meet the following criteria are more likely to fail expectant management and thus should not be considered for the NOM of uncomplicated acute appendicitis. These include the duration of symptoms before presenting to a surgical emergency , the presence of fever within 24 hours of presenting to a surgical emergency, TLC cells/dL, CRP mg/L, appendix diameter mm, modified Alvarado score , and adult appendicitis score .

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Detailed Description

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Expectant management with intravenous antibiotic therapy alone has emerged as an effective alternative to appendectomy for the treatment of uncomplicated acute appendicitis . It is important to identify patients at the onset of the disease who are likely to have successful outcomes for conservative management.

Conditions

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Conservative Management

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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(1) Male or female patients é diagnosis of acute appendicitis.

Patients who presented with complaints of right lower quadrant pain with symptoms and signs strongly suggestive of uncomplicated acute appendicitis that was confirmed on ultrasonography, were included. The modified Alvarado score and adult appendicitis score were calculated.

ceftriaxone

Intervention Type DRUG

ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly

Intervention Type DRUG

Conservative management

Interventions

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ceftriaxone

ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly

Intervention Type DRUG

ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly

Conservative management

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female patients é diagnosis of acute appendicitis .
* Patients with ages: from 16 to 60 years old.

Exclusion Criteria

* complicated AA (appendicolith, perforation, peri appendicular abscess or suspicion of a tumor).
* inflammatory bowel disease.
* inability to co-operate and give informed consent.
* diffuse peritonitis.
* antibiotic documented allergy \& allergy to contrast media .
* Patients with serious comorbid conditions DM \& renal insufficiency, serum creatinine \> 150 μmol/l .
* Pregnant \& lactating patient.
* Patients with bleeding diathesis and those on anticoagulants.
* Patients with advanced malignancies \& patient on immunosuppressive drugs .
* Patients with previous appendectomy.
* Extreme of age.

Minimum Eligible Age

16 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes