Brain Structural Abnormalities in Patients with Post-COVID-19 Headache
NCT ID: NCT06825741
Last Updated: 2025-02-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
60 participants
OBSERVATIONAL
2020-09-01
2022-12-31
Brief Summary
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Purpose: This study aims to identify the structural abnormalities observed in brain MRI that correlate with chronic headaches in patients who had COVID-19 infection.
Methods: The study included 30 patients with post-COVID-19 headaches and 30 control patients with no history of COVID-19. Demographic characteristics were analyzed using t-tests and chi-square tests. MRI findings were categorized into six types: cortical atrophy, white matter lesions, vascular lesions, lacunar lesions, vascular encephalopathy, and sinusitis. Differences in MRI findings between the two groups were evaluated using chi-square tests. Secondary outcomes included the analysis of symptoms accompanying headaches, diagnoses following MRI, and treatments applied.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Post-COVID-19 Headache Group
Participants in this group had a history of COVID-19 infection and developed persistent headaches afterward. They underwent brain MRI to assess potential structural abnormalities. Exclusion criteria included pre-existing neurological disorders or other conditions that could explain the headaches.
Observational Study - No intervention
This is an observational study evaluating brain structural abnormalities in post-COVID headache patients. No experimental intervention is applied.
Control Group
Participants in this group had no history of COVID-19 infection and no reported chronic headaches or neurological conditions. They underwent brain MRI for unrelated medical reasons and served as a comparison group to evaluate the prevalence of structural brain abnormalities in post-COVID headache patients.
Observational Study - No intervention
This is an observational study evaluating brain structural abnormalities in post-COVID headache patients. No experimental intervention is applied.
Interventions
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Observational Study - No intervention
This is an observational study evaluating brain structural abnormalities in post-COVID headache patients. No experimental intervention is applied.
Eligibility Criteria
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Inclusion Criteria
* History of COVID-19 infection
* Persistent headache following COVID-19 infection
* Brain MRI requested by the attending physician
Exclusion Criteria
* MRI contraindications (e.g., pacemaker, metal implants, claustrophobia)
18 Years
ALL
No
Sponsors
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University of Pecs
OTHER
Responsible Party
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Locations
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Szent Margit Hospital
Budapest, , Hungary
Countries
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References
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Szephelyi K, Kora S, Orsi G, Tollar J. Brain Structural Abnormalities in Patients with Post-COVID-19 Headache. Neurol Int. 2025 Mar 26;17(4):50. doi: 10.3390/neurolint17040050.
Other Identifiers
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IG/296-1/2025/1
Identifier Type: -
Identifier Source: org_study_id
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