Effect of Exercise on MiR-126 in Individuals With Prediabetes

NCT ID: NCT06809257

Last Updated: 2025-02-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-01

Study Completion Date

2023-04-30

Brief Summary

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This study aims to investigate the effect of a structured exercise program on microRNA-126 (miR-126) expression in individuals with prediabetes.

Detailed Description

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This study aims to investigate the effect of a structured exercise program on microRNA-126 (miR-126) expression in individuals with prediabetes. The hypothesis of our study is that regular aerobic exercise will increase miR-126 expression. Determining the effect of exercise on miR-126 in individuals with prediabetes will contribute to the elucidation of the pathways through which exercise is effective in prediabetes via epigenetic mechanisms.

Conditions

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Prediabetes microRNA Exercise

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Caregivers Outcome Assessors

Study Groups

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Exercise

Individuals in the intervention group were included in a planned aerobic exercise program for 12 weeks.This program was carried out under the supervision of specialist doctors, with the help of sports trainers and physiotherapists, and participants were given 60 minutes of moderate-intensity (50-70% of their maximum heart rate) aerobic exercise three days a week.

Group Type ACTIVE_COMPARATOR

Exercise

Intervention Type BEHAVIORAL

12 week moderately aerobik exercise

Control

No intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise

12 week moderately aerobik exercise

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Individuals who were newly diagnosed with prediabetes according to the Oral Glucose Tolerance Test (OGTT) and/or HbA1C criteria
* between the ages of 18-60
* were physically inactive (Level 1 according to the International Physical Activity Questionnaire)
* were motivated to exercise
* Individuals who had no obstacle to exercise as a result of the evaluation made by a cardiologist (ECG, exercise ECG test, etc.)
* and who did not show a change in body weight of more than ±2.5 kg in the last six months were included in the study.

Exclusion Criteria

* presence of serious medical conditions (e.g. advanced cancer, major neurological or endocrine disorders, respiratory failure)
* current cardiovascular disease, BMI \<19 kg/m²
* history of metformin use within the last 6 months
* receiving hormone replacement therapy
* life expectancy less than one year
* HIV positivity
* substance use
* or orthopedic and cognitive disorders that may prevent exercise
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

OTHER

Sponsor Role lead

Responsible Party

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Elif Yıldırım Ayaz

Assoc. Prof. Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Elif Yıldırım Ayaz

Role: PRINCIPAL_INVESTIGATOR

Sultan 2. Abdülhamid Han Training and Research Hospital

Locations

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Sultan 2. Abdülhamid Han Training and Research Hospital

Üsküdar, Istanbul, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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Saglik Bilimleri University

Identifier Type: OTHER

Identifier Source: secondary_id

EMiR-126-PD

Identifier Type: -

Identifier Source: org_study_id

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