Effects of Exercise and Metformin on Methylglyoxal Levels in Prediabetic Individuals
NCT ID: NCT06603480
Last Updated: 2024-09-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
96 participants
INTERVENTIONAL
2021-04-08
2022-12-07
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Aerobic Exercise
12 week aerobic exercise
Exercise
Aerobic exercise (moderate intensity) at 50-70% of maximum heart rate for 60 minutes, 3 days a week for 12 weeks
Metformin
Metformin 2\*1 given
Metformin
Patients who started Metformin 2\*1
Control
Only routine
No interventions assigned to this group
Interventions
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Exercise
Aerobic exercise (moderate intensity) at 50-70% of maximum heart rate for 60 minutes, 3 days a week for 12 weeks
Metformin
Patients who started Metformin 2\*1
Eligibility Criteria
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Inclusion Criteria
* who were assessed as physically inactive (Level 1) according to the International Physical Activity Questionnaire
* who had sufficient motivation to participate in the exercise program (assessed by one-on-one interviews conducted by the researchers),
* who were deemed suitable to participate in the exercise program after a cardiac examination by a cardiologist (with resting electrocardiogram and questioning of cardiac symptoms, and advanced tests such as exercise electrocardiogram test when necessary),
* who had the same weight (±2.5 kg) for 6 months before participating in the study.
Exclusion Criteria
* having used metformin for 6 months before the study, having cardiovascular disease,
* heart failure, cancer, having a BMI \<19 kg/m2, receiving hormone replacement therapy,
* having a life expectancy of less than 1 year, being HIV positive, substance use,
* functional dependence, having an orthopedic disease that prevents physical activity,
* having cognitive impairment and other diseases that would affect the study results (respiratory diseases, muscle diseases, non-alcoholic fatty liver disease, etc.),
* using medications or supplements that would affect the study results.
18 Years
60 Years
ALL
No
Sponsors
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Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
OTHER
Responsible Party
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Locations
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Sultan 2. Abdülhamid Han Training and Research Hospital
Üsküdar, Istanbul, Turkey (Türkiye)
Countries
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Other Identifiers
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MEGS
Identifier Type: -
Identifier Source: org_study_id
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