The Effect of Cycling, Running, and Playing Rugby on Three Biomarkers That May Indicate Brain Injury
NCT ID: NCT06804291
Last Updated: 2025-02-03
Study Results
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Basic Information
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COMPLETED
NA
32 participants
INTERVENTIONAL
2021-10-16
2022-02-15
Brief Summary
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Do NfL, BLBP, and APP increase following exercise? Researchers compared the accumulation of NfL, BLBP, and NfL among runners, cyclists, rugby players, controls, and between sexes in each category.
Participants were asked to either run, bike, play a rugby match, or abstain from exercise. In the exercising group, blood was drawn from a vein prior to the activity, immediately after the activity, 30 minutes after the activity, 1 hour after the activity, 24 hours after the activity, 48 hours after the activity, and 72 hours after the activity. In the non-exercising group blood was drawn from a vein one time.
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Detailed Description
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Blood was drawn from an antecubital vein in the exercising groups before and after exercise as well as 30 minutes, 1-, 24-, 48-, and 72-hours after exercise. Only one blood draw was taken in the control group.
The blood biomarkers neurofilament light (NfL), brain lipid binding protein (BLBP), and amyloid precursor protein were then measured in the venous blood and compared within groups, among groups, and between sexes.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Running Group
Participants run 6.44 kilometers. Venous blood is drawn prior to the run, immediately after the run, 30 minutes after the run, and 1-, 24-, 48, and 72-hours after the run.
Running
Participants were expected to run 6.44 kilometers.
Cycling Group
Participants cycle 39 kilometers. Venous blood is drawn prior to cycling, immediately after cycling, 30 minutes after cycling, and 1-, 24-, 48, and 72-hours after cycling.
Cycling
Participants were expected to cycle 39 kilometers
Rugby Group
Participants play one rugby match. Venous blood is drawn prior to the match, immediately after the match, 30 minutes after the match and 1-, 24-, 48, and 72-hours after the match.
Rugby
Participants were expected to play in one rugby match.
Control Group
Participants refrained from exercise for 24 hours followed by one blood draw.
control group
Participants were asked to refrain from exercise for 24 hours.
Interventions
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Running
Participants were expected to run 6.44 kilometers.
Cycling
Participants were expected to cycle 39 kilometers
Rugby
Participants were expected to play in one rugby match.
control group
Participants were asked to refrain from exercise for 24 hours.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Those in the running group must be able to run 6.44 kilometers
* Those in the cycling group must be able to cycle 39 kilometers
* Those in the ruby group must be members of the university club rugby team
Exclusion Criteria
* Individuals with heart disease
* Individuals who are pregnant
* Individuals who get light-headed or dizzy while donating blood
18 Years
ALL
Yes
Sponsors
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Appalachian State University
OTHER
Responsible Party
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Matthew Rogatzki
Assistant Professor
Locations
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Appalachian State University
Boone, North Carolina, United States
Countries
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Other Identifiers
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21-0286
Identifier Type: -
Identifier Source: org_study_id
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