" Acute Brain Changes After Repetitive Headers in Soccer and the Effects of a Protective Device "

NCT ID: NCT04426188

Last Updated: 2021-03-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-06-04

Study Completion Date

2021-01-15

Brief Summary

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Soccer, the most popular sport in the world, exposes players to repeated head impacts and concussions, due to contact with another player or with the ground. Moreover, routine game-play in soccer involves intentional and repeated head impacts through ball "heading", with frequent high velocities, which might cause a transient brain dysfunction. In this pre-post prospective interventional study, 22 soccer players will perform 10 headers from machine-projected soccer balls at standardized speeds, modelling routine soccer practice. They will perform heading series in 2 different oral conditions, on different days at least 1 week apart: 1) Without mouthguard and tight jaws ; 2) With mouthguard and tight jaws. The strength of the neck muscles will be measured before the heading series. The kinematic of the movement will be recorded during each impact during the 2 heading series, as well as the activity of the jaw muscles which will be recorded by electromyogram. Before and after each heading series, electrophysiological data, multimodal magnetic resonance imaging (MRI), and cognitive computerized assessment will be acquired

Detailed Description

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Conditions

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Traumatic Brain Injury Concussion, Brain

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Without mouthguard

Heading series without mouthguard from machine-projected soccer balls at standardized speeds

Group Type SHAM_COMPARATOR

Heading series

Intervention Type PROCEDURE

10 headers from machine-projected soccer balls at standardized speeds

Magnetic Resonance Imaging (MRI)

Intervention Type DEVICE

Brain MRI before and after a series

Cognitive computerized assessment

Intervention Type OTHER

Cognitive evaluation carried out with two computerized tools

Electrophysiological records

Intervention Type PROCEDURE

Electrophysiological recording of Motor Evoked Potentials consisting of the application of transcranial magnetic stimulations (TMS) and the collection of muscle activity by electromyogram (EMG)

Dynamometer

Intervention Type DEVICE

Measure of the strength of the neck muscles using a dynamometer

With mouthguard

Heading series with mouthguard from machine-projected soccer balls at standardized speeds

Group Type EXPERIMENTAL

Heading series

Intervention Type PROCEDURE

10 headers from machine-projected soccer balls at standardized speeds

Magnetic Resonance Imaging (MRI)

Intervention Type DEVICE

Brain MRI before and after a series

Cognitive computerized assessment

Intervention Type OTHER

Cognitive evaluation carried out with two computerized tools

Electrophysiological records

Intervention Type PROCEDURE

Electrophysiological recording of Motor Evoked Potentials consisting of the application of transcranial magnetic stimulations (TMS) and the collection of muscle activity by electromyogram (EMG)

Dynamometer

Intervention Type DEVICE

Measure of the strength of the neck muscles using a dynamometer

Interventions

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Heading series

10 headers from machine-projected soccer balls at standardized speeds

Intervention Type PROCEDURE

Magnetic Resonance Imaging (MRI)

Brain MRI before and after a series

Intervention Type DEVICE

Cognitive computerized assessment

Cognitive evaluation carried out with two computerized tools

Intervention Type OTHER

Electrophysiological records

Electrophysiological recording of Motor Evoked Potentials consisting of the application of transcranial magnetic stimulations (TMS) and the collection of muscle activity by electromyogram (EMG)

Intervention Type PROCEDURE

Dynamometer

Measure of the strength of the neck muscles using a dynamometer

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

Male 18 to 25 years, enrolled in French Social Security, recruited from the soccer teams of the University of Bordeaux

Exclusion Criteria

* Abnormal neurological examination
* Taking drugs targeting the central nervous system
* Any unhealed injury
* History of head trauma, or other notion of central nervous system injury
* History of severe high blood pressure, diabetes, chronic cardiovascular pathology, progressive or debilitating disease
* Family history of epilepsy
* Contraindication to MRI: head circumference\> 60 - Claustrophobia - Pacemaker, Implantable Neurostimulation, Implantable Defibrillator - Cochlear Implants - Ocular or cerebral ferromagnetic foreign body - refusal to be informed of an anomaly detected with MRI
* Individuals under legal protection or unable of giving their informed consent
Minimum Eligible Age

18 Years

Maximum Eligible Age

25 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Bordeaux

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hélène CASSOUDESALLE

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Bordeaux

Locations

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CHU de Bordeaux

Bordeaux, , France

Site Status

Countries

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France

Other Identifiers

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CHUBX 2019/45

Identifier Type: -

Identifier Source: org_study_id

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