Pilot Study Evaluating brainQuant's Ability to Detect Alterations in White Matter in Diffusion MRI, Indicative of Post-traumatic Lesions

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-10

Study Completion Date

2028-03-31

Brief Summary

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Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease described in boxing, but also in contact sports such as American football.

Soccer, due to repeated headers, could also be associated, albeit to a lesser degree, with the development of this type of pathology.

Indeed, it has been shown that playing soccer can be accompanied by cognitive impairments, and neurodegenerative brain abnormalities have been described in neuropathology studies of former professional soccer players. Subradiological brain abnormalities have been found in multimodal MRI in various sports. Similarly, a decrease in cognitive performance has been described.

The discovery of this type of anomaly in a population of professional footballers nearing the end of their careers could lead to:

* The implementation of appropriate monitoring for professional footballers through early detection of lesions via MRI and cognitive disorders
* The implementation of preventative measures for professional footballers, but also for amateur footballers from a very young age.

Detailed Description

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Conditions

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Chronic Traumatic Encephalopathy

Keywords

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Chronic Traumatic Encephalopathy Post-traumatic lesions Neurodegenerative brain abnormalities Professional soccer players

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Male subject
* Aged 32 to 60 years inclusive
* Professional footballer nearing the end of their career or recently retired, or subject who has never regularly participated in sports that expose them to head trauma (particularly rugby, basketball, handball, American football, hockey, combat sports, etc.)

Exclusion Criteria

\- Subject who expressed their opposition to participating in the study

Minimum Eligible Age

32 Years

Maximum Eligible Age

60 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Locations

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Service d'Imagerie 2 - Réanimation - CHU de Strasbourg - France

Strasbourg, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Stéphane KREMER, MD, PhD

Role: CONTACT

Phone: 33 3 88 12 78 48

Email: [email protected]

Facility Contacts

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Stéphane KREMER, Stéphane KREMERMD, PhD

Role: primary

Other Identifiers

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9451

Identifier Type: -

Identifier Source: org_study_id