Top Set and Parkinson's Disease

NCT ID: NCT06801704

Last Updated: 2025-08-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-01-28

Study Completion Date

2025-06-30

Brief Summary

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This project will focus on improving power in adults with Parkinson's disease, since power is related to performance of daily activities and memory and decision making. The study will compare traditional power training, where the participant does all exercises as fast as possible to top set resistance training, where the participant does power training, but it is preceded by warm-up sets that progress in weight until the participant reaches 90% of the person's maximum strength. If the top set method is better than traditional power training, it could be more beneficial than existing methods in improving independence in adults with Parkinson's disease.

Detailed Description

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Conditions

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Parkinson Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Top Set Resistance Training

Participants will be in this group receiving the top set resistance training for up to 12 weeks.

Group Type OTHER

Top Set Resistance Training

Intervention Type BEHAVIORAL

Participants will receive four warm-up sets at increasingly higher resistance, followed by three sets of eight repetitions per set on six resistance-training exercises. During training participants will be allowed 1-minute rests between sets. Participants will come in person for up to 12 weeks, twice per week, for approximately 45 minutes per day.

Power Resistance Training

Participants will be in this group receiving the power resistance training for up to 12 weeks.

Group Type OTHER

Power Resistance Training

Intervention Type BEHAVIORAL

Participants will receive a total of 24 in-person training sessions using three sets of eight repetitions per set on six power resistance-training exercises. During training participants will be allowed 1-minute rests between sets. Participants will come in person for up to 12 weeks, twice per week, for approximately 45 minutes per day.

Interventions

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Top Set Resistance Training

Participants will receive four warm-up sets at increasingly higher resistance, followed by three sets of eight repetitions per set on six resistance-training exercises. During training participants will be allowed 1-minute rests between sets. Participants will come in person for up to 12 weeks, twice per week, for approximately 45 minutes per day.

Intervention Type BEHAVIORAL

Power Resistance Training

Participants will receive a total of 24 in-person training sessions using three sets of eight repetitions per set on six power resistance-training exercises. During training participants will be allowed 1-minute rests between sets. Participants will come in person for up to 12 weeks, twice per week, for approximately 45 minutes per day.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Confirmed diagnosis of Parkinson's disease
* Between the ages of 30-90 years of age
* A Hoehn and Yahr score of ≤3, which will be provided by the participant's medical provider within 1 year of the study's inception.

Exclusion Criteria

* Uncontrolled cardiovascular disease that prevents participation in a training program
* Documented HIV infection or another immunodeficiency syndrome
* Other neuromuscular diseases besides Parkinson's disease
* Current musculoskeletal injury that prevents exercise.
* Having a pacemaker
* Pregnancy
* Incarcerated individuals
* Montreal Cognitive Assessment Score below 18
Minimum Eligible Age

30 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Miami

OTHER

Sponsor Role lead

Responsible Party

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Joseph Signorile

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Joseph F. Signorile, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Miami

Locations

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Laboratory of Neruomuscular Research and Active Aging

Coral Gables, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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20241248

Identifier Type: -

Identifier Source: org_study_id

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