Nasal vs Oral Breathing in Drug Induced Sleep vs Natural Sleep

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-11-20

Study Completion Date

2026-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This project will provide important new information regarding (1) the relationship between route of breathing and airway collapsibility and (2) whether route of breathing during DISE (Drug-Induced Sleep Endoscopy) is representative of natural sleep.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Mechanisms of Upper Airway Obstruction

NCT04322097

Obstructive Sleep Apnea

COMPLETED NA

Comparison Between Natural Sleep Endoscopy and Drug-induced Sleep Endoscopy in Patients With Obstructive Sleep Apnea

NCT04729478

Sleep Apnea, Obstructive Sleep Apnea Sleep Apnea Syndromes +13 more

UNKNOWN NA

The Role of the Nose in Snoring and Sleep Apnea

NCT03072173

Nasal Obstruction Apnea, Obstructive Sleep

UNKNOWN NA

Correlation Between Upper Airway Endoscopy and Physiological Traits of Obstructive Sleep Apnea

NCT04753684

Obstructive Sleep Apnea

COMPLETED

DISE: Phenotyping Obstruction Patterns

NCT05050383

Obstructive Sleep Apnea

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

As part of standard of care, a drug-induced sleep endoscopy will be done, where route of breathing will be determined as a percentage of total breaths (during baseline, lateral sleep and maneuver). As part of the research procedure, an in-laboratory Polysomnogram will be conducted as study procedure including a oronasal pressure signal cannula to assess route of breathing.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Sleep Apnea, Obstructive

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* • Adults (≥ 18yrs) that underwent clinical evaluation at the CPAP Alternatives Clinic at Penn Otorhinolaryngology.

* Must have at least mild OSA (AHI\>5)

Exclusion Criteria

* • Sleep study with an AHI\<5, \>25% of total events being central or mixed events, or inability to achieve adequate drug-induced sleep.

* Upper Respiratory Illness at the time of the DISE.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No