Accelerated Aging in Middle-Aged Men With Sleep-disordered Breathing.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

53 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2014-01-31

Brief Summary

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Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors (diabetes, hypertension, dyslipidemia, obesity), promoting themselves aging. The investigators propose to compare a group of OSAS patients free of any associated pathology, to subjects matched for age, sex, smoking and body mass index (BMI)

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Detailed Description

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Conditions

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Obstructive Sleep Apnea

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Severe OSA

Patients with severe OSA (AHI \> 30)

Group Type OTHER

Polysomnography , blood collection, bone densitometry and Functional respiratory explorations

Intervention Type OTHER

Blood collection, Bone densitometry and Functional respiratory explorations are a specific interventions of protocol for the 3 arms. Polysomnography is a specific intervention for the arms " healthy volunteers "

Moderate OSA

Patients with moderate OSA (5 \< AHI ≤ 30)

Group Type OTHER

Polysomnography , blood collection, bone densitometry and Functional respiratory explorations

Intervention Type OTHER

Blood collection, Bone densitometry and Functional respiratory explorations are a specific interventions of protocol for the 3 arms. Polysomnography is a specific intervention for the arms " healthy volunteers "

Healthy volunteers

Healthy volunteers (AHI ≤ 5)

Group Type OTHER

Polysomnography , blood collection, bone densitometry and Functional respiratory explorations

Intervention Type OTHER

Blood collection, Bone densitometry and Functional respiratory explorations are a specific interventions of protocol for the 3 arms. Polysomnography is a specific intervention for the arms " healthy volunteers "

Interventions

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Polysomnography , blood collection, bone densitometry and Functional respiratory explorations

Blood collection, Bone densitometry and Functional respiratory explorations are a specific interventions of protocol for the 3 arms. Polysomnography is a specific intervention for the arms " healthy volunteers "

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Patient:

* Men aged 20 to 65 years
* Having polysomnography in the Functional Explorations department, Sleep Laboratory, Hospital Henri Mondor, Creteil
* With an AHI \> 5 / h

Healthy volunteers:

* Men aged 20 to 65 years
* With an AHI ≤ 5 / h

Exclusion Criteria

All subjects:

* Known cardiovascular risk: hypertension treated, diabetes treated, dyslipidemia treated,
* Known cardiovascular disease associated (heart failure, rhythm disorder ...)
* Known respiratory diseases
* Known neoplastic pathology, known chronic inflammatory disease
* Psychiatric pathology treated
* Medication
* Not affiliated to the French social health care system
* Major protected person
* Private person of liberty
* People in emergency situation
* Patient refusing to participate in the study

Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes