Conservative Treatment for Atlantoaxial Dislocation Patients Without Neurological Deficit
NCT ID: NCT06772311
Last Updated: 2025-01-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
300 participants
OBSERVATIONAL
2025-01-15
2030-12-31
Brief Summary
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Is surgical intervention always necessary in atlantoaxial dislocation patients without nerve deficit?
Patients who refuse surgical intervention will continue to be treated conservatively. Clinical outcomes will be summarized over five years of follow-up
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Conservative Treatment Group
Patients who declined surgery and request conservative treatment and observation.
No interventions assigned to this group
Surgical Intervention Group
Patients who request surgical intervention.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* The patients have no clinical manifestations of the nervous system, including occipital neuralgia, manifestations of cranial nerve impairment (such as dysphagia, dysarthria, nystagmus, etc.) and manifestations of spinal cord impairment (such as unsteadiness in holding objects, unsteady gait, decreased limb muscle strength, etc.).
* After fully understanding their own conditions as well as the advantages, disadvantages and risks of both conservative treatment and surgical treatment, the patients can choose the initial treatment method on their own. If they choose conservative treatment, they will be included in the conservative treatment. If they choose surgical treatment, they will be included in the surgical intervention group.
Exclusion Criteria
* Patients with infections or tumors in the cranio-cervical junction.
* Patients with fresh fractures in the cranio-cervical junction.
* Patients with clinical manifestations of nerve deficit.
* Patients with severe diseases in other spinal regions such as the thoracic and lumbar spine that affect their clinical symptoms; patients with motor neuron diseases like amyotrophic lateral sclerosis and other severe neurological diseases.
* Patients who have participated in other clinical trials within the recent three months.
* Patients with mental disorders whose cognitive impairments (or those of their legal guardians) prevent them from giving full informed consent.
* Patients who refuse to participate in this study.
ALL
No
Sponsors
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The First Affiliated Hospital of Zhengzhou University
OTHER
Shanxi Medical University Second Hospital
UNKNOWN
Sir Run Run Shaw Hospital
OTHER
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
OTHER
Hebei Medical University Third Hospital
OTHER
Shanxi Bethune Hospital
OTHER
Daping Hospital of Army Medical University
OTHER
Shengjing Hospital
OTHER
Tianjin People's Hospital
OTHER
First Affiliated Hospital of Kunming Medical University
OTHER
Affiliated hospital of Guilin medical university,China
UNKNOWN
Peking University Third Hospital
OTHER
Responsible Party
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Wang Shenglin
Professor
Locations
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Peking University Third Hospital
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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M20248745
Identifier Type: -
Identifier Source: org_study_id
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