A Study on Diagnosis and Treatment Strategies for Atlantoaxial Dislocation

NCT ID: NCT06233539

Last Updated: 2024-04-03

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 3000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-12-01
• Study Completion Date: 2026-12-31

Brief Summary

The most effective treatment for atlantoaxial dislocation is surgical treatment, with the principle of achieving reduction, reconstruction, and fusion of the atlantoaxial joint. The surgical strategies mainly include simple anterior approach, simple posterior approach, and combined anterior posterior approach. The investigators have summarized 904 cases of atlantoaxial instability or dislocation from 1998 to 2010 and preliminarily published the diagnosis and treatment strategy tree of the Third Hospital of Beijing Medical University. This strategy is divided into four types based on the severity of atlantoaxial dislocation: unstable, reversible, difficult to recover, and skeletal, and enters different surgical treatment processes. With the increase in the number of cases, accumulation of experience, and technological improvements in the past decade, spinal surgery colleagues have updated their classification diagnosis, diagnosis and treatment processes, and surgical techniques for atlantoaxial instability or dislocation.

However, the selection of treatment strategies for atlantoaxial dislocation is mostly based on the surgeon's own experience, and there is a lack of standardized, large-scale, and high-level evidence-based medical research on the safety and effectiveness of current empirical strategies. Based on this, this study intends to adopt a multicenter, retrospective, and prospective study to construct a high-quality clinical cohort of atlantoaxial dislocation, update the classification and diagnosis and treatment strategies of atlantoaxial dislocation. And conduct long-term follow-up on patients to evaluate their safety and effectiveness, guide the surgical treatment of atlantoaxial dislocation, and thus form a recognized diagnostic and treatment standard for atlantoaxial dislocation.

Conditions

Atlantoaxial Dislocation; Treatment; Diagnostic

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: OTHER

Study Groups

Retrospective section

Observational research without intervention

Intervention Type: OTHER

Observational research without intervention

Prospective section

Observational research without intervention

Intervention Type: OTHER

Observational research without intervention

Interventions

Observational research without intervention

Observational research without intervention

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patients diagnosed with atlantoaxial dislocation and treated with surgery

Exclusion Criteria

• Disagree to participate in this study.

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Peking University Third Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Shenglin Wang

Beijing, Beijing Municipality, China

Site Status: RECRUITING

Countries

China

Facility Contacts

Shenglin Wang

Role: primary

pkuwsl@126.com

+8613501380281

Other Identifiers

M2022822

Identifier Type: -

Identifier Source: org_study_id