The Clinical Study of Botulinum Toxin Type A Injection in the Treatment of Wilson Disease

NCT ID: NCT06762509

Last Updated: 2025-01-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-12-01

Study Completion Date

2024-01-01

Brief Summary

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In order to expand the treatment of Wilson disease and improve the quality of life of patients with Wilson's disease, the clinical effect of botulinum toxin type A injection on Wilson's disease was discussed.

Detailed Description

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Conditions

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Wilson Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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botulinum toxin type A

Enrolled patients were given basic copper discharge treatment, including sodium dimercaptopropyl sulfonate injection, dimercaptosuccinic acid capsules, zinc gluconate tablets, benzoxol hydrochloride tablets, etc. Local injection of botulinum toxin type A was given at the time of enrollment.

Placebo Comparator: Control group Arm Description: Enrolled patients were treated with DMPS basic copper expulsion therapy, including sodium dithioglycolate injection, dithioglycolic acid capsules, zinc gluconate tablets, benzoxol hydrochloride tablets, etc.

Botulinum toxin type A

Intervention Type DRUG

Local injection of botulinum toxin type A was given at the time of enrollment

Enrolled patients were treated with DMPS basic copper expulsion therapy

Enrolled patients were treated with DMPS basic copper expulsion therapy, including sodium dithioglycolate injection, dithioglycolic acid capsules, zinc gluconate tablets, benzoxol hydrochloride tablets, etc.

No interventions assigned to this group

Interventions

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Botulinum toxin type A

Local injection of botulinum toxin type A was given at the time of enrollment

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Inclusion Criteria:1.Conform to the diagnosis of "2012 European Liver Study Guidelines for Diagnosis and Treatment of hepatolenticular degeneration". 2. Aged from 15 to 65 years.

Exclusion Criteria:Non-Wilson's disease
Minimum Eligible Age

15 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine

OTHER

Sponsor Role lead

Responsible Party

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Jun Li

Chief physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, #117 Meishan Street, Shushan District Hefei 230037, China

Hefei, , China

Site Status

Countries

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China

Other Identifiers

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gxgwfx2021028

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

BTTA

Identifier Type: -

Identifier Source: org_study_id

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