Study to Evaluate Safety, Efficacy of Botulinum Toxin Type A in Patients With Cervical Dystonia

NCT ID: NCT00564681

Last Updated: 2016-01-05

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

242 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-12-31

Study Completion Date

2009-12-31

Brief Summary

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Study is to investigate the use of the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) scale in a cervical dystonia population treated with botulinum toxin type A, and placebo.

Detailed Description

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Conditions

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Cervical Dystonia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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botulinum toxin Type A

Intramuscular injections into the affected muscles. Maximum dose of 360 units. Subjects may receive up to three treatments.

Group Type ACTIVE_COMPARATOR

botulinum toxin type A

Intervention Type BIOLOGICAL

Intramuscular injections into the affected muscles. Maximum dose of 360 units. Subjects may receive up to three treatments.

botulinum toxin Type A Formulation 2

Intramuscular injections into the affected muscles. Maximum dose of 360 units. Subjects may receive up to three treatments.

Group Type ACTIVE_COMPARATOR

botulinum toxin type A Formulation 2

Intervention Type BIOLOGICAL

Intramuscular injections into the affected muscles. Maximum dose of 360 units. Subjects may receive up to three treatments.

Placebo (Normal Saline) / botulinum toxin Type A

Intramuscular injections of the assigned study medication into the affected muscles (placebo for treatment cycle 1 and botulinum toxin Type A for subsequent treatments). Maximum dose of 360 units. Subjects may receive up to three treatments.

Group Type OTHER

botulinum toxin type A

Intervention Type BIOLOGICAL

Intramuscular injections into the affected muscles. Maximum dose of 360 units. Subjects may receive up to three treatments.

Normal Saline

Intervention Type DRUG

Intramuscular injections of placebo (normal saline) into the affected muscles for treatment cycle 1.

Placebo (Normal Saline) / botulinum toxin Type A Formulation 2

Intramuscular injections of the assigned study medication into the affected muscles (placebo for treatment cycle 1 and botulinum toxin Type A Formulation 2 for subsequent treatments). Maximum dose of 360 units. Subjects may receive up to three treatments.

Group Type OTHER

botulinum toxin type A Formulation 2

Intervention Type BIOLOGICAL

Intramuscular injections into the affected muscles. Maximum dose of 360 units. Subjects may receive up to three treatments.

Normal Saline

Intervention Type DRUG

Intramuscular injections of placebo (normal saline) into the affected muscles for treatment cycle 1.

Interventions

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botulinum toxin type A

Intramuscular injections into the affected muscles. Maximum dose of 360 units. Subjects may receive up to three treatments.

Intervention Type BIOLOGICAL

botulinum toxin type A Formulation 2

Intramuscular injections into the affected muscles. Maximum dose of 360 units. Subjects may receive up to three treatments.

Intervention Type BIOLOGICAL

Normal Saline

Intramuscular injections of placebo (normal saline) into the affected muscles for treatment cycle 1.

Intervention Type DRUG

Other Intervention Names

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BOTOX®

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of cervical dystonia

Exclusion Criteria

* Current or previous botulinum toxin treatment of any type for any condition
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Allergan

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Allergan

Locations

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Winston-Salem, North Carolina, United States

Site Status

Halifax, Nova Scotia, Canada

Site Status

Prague, , Czechia

Site Status

Berlin, , Germany

Site Status

Budapest, , Hungary

Site Status

Mumbai, , India

Site Status

Manila, , Philippines

Site Status

Warsaw, , Poland

Site Status

Moscow, , Russia

Site Status

Belgrade, , Serbia

Site Status

Singapore, , Singapore

Site Status

Spisska Nova, , Slovakia

Site Status

Cape Town, , South Africa

Site Status

Tainan City, , Taiwan

Site Status

Bangkok, , Thailand

Site Status

Bristol, , United Kingdom

Site Status

Countries

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United States Canada Czechia Germany Hungary India Philippines Poland Russia Serbia Singapore Slovakia South Africa Taiwan Thailand United Kingdom

Other Identifiers

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191622-090

Identifier Type: -

Identifier Source: org_study_id

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