Study to Assess the Efficacy and Safety of Dysport® in Cervical Dystonia

NCT ID: NCT00447772

Last Updated: 2023-03-30

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

516 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-10-31

Study Completion Date

2008-04-30

Brief Summary

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The aim is to demonstrate equivalent efficacy and safety in the treatment of the two most frequent forms of cervical dystonia (predominantly rotational torticollis and predominantly laterocollis) with the standard initial dose of 500 units Dysport®. The patients will be assigned to one of the two basic types of cervical dystonia, either predominantly rotational torticollis or predominantly laterocollis on the basis of clinical examination. This will determine which therapy is to be administered, using the clearly defined, structured injection protocols.

Detailed Description

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Conditions

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Cervical Dystonia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

Botulinum toxin type A

Intervention Type BIOLOGICAL

Active Drug: Botulinum type A toxin (Dysport®) 500 Units / 2.5 ml injected in muscles involved in cervical dystonia

Interventions

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Botulinum toxin type A

Active Drug: Botulinum type A toxin (Dysport®) 500 Units / 2.5 ml injected in muscles involved in cervical dystonia

Intervention Type BIOLOGICAL

Other Intervention Names

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AbobotulinumtoxinA (Dysport®)

Eligibility Criteria

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Inclusion Criteria

* De novo patients with cervical dystonia
* Outpatient
* Patients to be of age 18 years or older
* Written informed consent to participate in the study

Exclusion Criteria

* Pre-treatment of cervical dystonia with botulinum toxin
* Pre-treatment with botulinum toxin for any indication other than cervical dystonia within the past 12 months
* Pure retro- or antecollis
* Neurological or other diseases which may affect head and neck motor function or neuromuscular transmission, e.g. polyneuropathy with pareses, myasthenia, myopathy, motor neurone diseases, Bekhterev's disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ipsen

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ipsen Medical Director

Role: STUDY_DIRECTOR

Ipsen

Locations

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Krankenhaus der Barmherzigen Brüder

Graz, , Austria

Site Status

NÖ LKH Grimmenstein-Hochegg

Grimmenstein, , Austria

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Univ.-Klinik für Neurologie

Innsbruck, , Austria

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Konventhospital der Barmherzigen Brüder

Linz, , Austria

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O.Ö. Landes-Nervenklinik Wagner-Jauregg

Linz, , Austria

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Neurolog. Klinik des RWTH Aachen

Aachen, , Germany

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Praxis für Anästhesiologie

Ahaus, , Germany

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Praxis für Neurologie und Psychiatrie

Apolda, , Germany

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Sächsisches Krankenhaus

Arnsdorf, , Germany

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Praxis für Neurologie

Aschaffenburg, , Germany

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Klinikum für Rehabilitation

Bad Oeynhausen, , Germany

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Praxis für Neurologie

Bad Reichenhall, , Germany

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Krankenhaus Hohe Warte

Bayreuth, , Germany

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Neurologische Rehabilitationsklinik

Beelitz, , Germany

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NRZ Neurologisches Rehabilitationszentrum Leipzig

Bennewitz, , Germany

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Praxis für Neurologie

Berlin, , Germany

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Neurologisches Facharztzentrum am St.-Gertrauden-KH

Berlin, , Germany

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Praxis für Neurologie

Berlin, , Germany

Site Status

Universitätsklinikum Charité, Campus Benjamin Franklin

Berlin, , Germany

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Universitätsklinikum Charité, Campus Virchow-Klinikum

Berlin, , Germany

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Gemeinschaftspraxis für Neurologie

Berlin, , Germany

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Krankenhaus Henningsdorf

Berlin, , Germany

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SALUS Fachkrankenhaus Bernburg

Bernburg, , Germany

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Neurologische Klinik GILEAD im Evang. KH Bielefeld EVKB

Bielefeld, , Germany

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Praxis für Neurologie

Bochum, , Germany

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Berufsg. Kliniken Bergmannsheil

Bochum, , Germany

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St.-Josef-Hospital

Bochum, , Germany

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Medizinische Einrichtung Rhein. F.-Wilhelms-Universität Bonn

Bonn, , Germany

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Zentralkrankenhaus Bremen-Ost

Bremen, , Germany

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Klinikum Chemnitz gGmbH

Chemnitz, , Germany

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Klinikum Koeln-Merheim

Cologne, , Germany

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Praxis für Neurologie

Dachau, , Germany

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Bezirksklinikum Mainkofen

Deggendorf, , Germany

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Universitätsklinikum Carl Gustav Carus

Dresden, , Germany

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Malteser Krankenhaus St. Anna

Duisburg, , Germany

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University Hospital, Neurology Clinic

Düsseldorf, , Germany

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Landesklinik Eberswalde

Eberswalde, , Germany

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HELIOS Klinikum Erfurt

Erfurt, , Germany

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Uniklinik Erlangen

Erlangen, , Germany

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Alfried-Krupp-Krankenhaus

Essen, , Germany

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Universitätsklinik Essen

Essen, , Germany

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Kreiskrankenhaus Freiberg

Freiberg, , Germany

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Zentrum für Neurologie

Giessen, , Germany

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Praxis für Neurologie

Giessen, , Germany

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Praxis für Neurologie und Psychiatrie

Giessen, , Germany

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Sächsisches Krankenhaus für Psychiatrie, Psychotherapie und Neurolgie

Großschweidnitz, , Germany

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Bezirkskrankenhaus Günzburg

Günzburg, , Germany

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Klinikum Ambrock

Hagen, , Germany

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Katholisches Krankenhaus Hagen

Hagen, , Germany

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Städt. Krankenhaus Martha-Maria

Halle, , Germany

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Gemeinschaftspraxis für Neurologie

Hamburg, , Germany

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Praxis für Neurologie

Hamburg, , Germany

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Neurologische Uniklinik

Hanover, , Germany

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Praxis für Neurologie

Hanover, , Germany

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Universitätskliniken des Saarlandes

Homburg, , Germany

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Gemeinschaftspraxis für Neurologie/Psychiatrie

Ilmenau, , Germany

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Praxis für Neurologie

Itzehoe, , Germany

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Uniklinik Jena

Jena, , Germany

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Westpfalz-Klinikum GmbH

Kaiserslautern, , Germany

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Universitätsklinikum Kiel

Kiel, , Germany

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Kath. Klinikum/Brüderkrankenhaus

Koblenz, , Germany

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Neurologische Praxis

Landshut, , Germany

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Universitätsklinikum Leipzig

Leipzig, , Germany

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Gemeinschaftspraxis für Neurologie/Psychiatrie

Leipzig, , Germany

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Gemeinschaftspraxis für Neurologie

Leipzig, , Germany

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Klinikum Lippe-Lemgo GmbH

Lemgo, , Germany

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Klinikum der Stadt Ludwigshafen

Ludwigshafen, , Germany

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Universitätsklinikum

Lübeck, , Germany

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Gemeinschaftspraxis für Neurologie/Psychiatrie

Lüneburg, , Germany

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Universitätsklinikum

Magdeburg, , Germany

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Universitätsklinikum

Mainz, , Germany

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Klinikum Mannheim

Mannheim, , Germany

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Praxis für Neurologie

Mannheim, , Germany

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Klinikum Minden

Minden, , Germany

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Kliniken Maria Hilf GmbH

Mönchengladbach, , Germany

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Neurologisches Krankenhaus München

München, , Germany

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Klinikum rechts der Isar

München, , Germany

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Universitätsklinikum Münster

Münster, , Germany

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Praxis für Neurologie und Nervenheilkunde

Neubrandenburg, , Germany

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Klinikum Nürnberg-Süd

Nuremberg, , Germany

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Evangelisches Krankenhaus Oldenburg

Oldenburg, , Germany

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Praxis für Neurologie und Psychiatrie

Ostfildern, , Germany

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St. Vincenz-Krankenhaus GmbH

Paderborn, , Germany

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St.-Josefs-Krankenhaus

Potsdam, , Germany

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Klinikum Ernst von Bergmann

Potsdam, , Germany

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Zentrum für Psychiatrie Weissenau

Ravensburg, , Germany

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Knappschafts-Krankenhaus

Recklinghausen, , Germany

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Universitätsklinikum

Rostock, , Germany

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Evang.-Freichkirchl. Krankenhaus

Rüdersdorf, , Germany

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Praxis für Neurologie

Schorndorf, , Germany

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Klinikum Uckermark GmbH

Schwedt, , Germany

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HELIOS Kliniken Schwerin

Schwerin, , Germany

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Asklepios Kliniken Schildautal

Seesen, , Germany

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EMSA

Singen, , Germany

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Landesfachkrankenhaus für Psychatrie und Neurologie

Stadtroda, , Germany

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Praxis für Neurologie

Stralsund, , Germany

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Neurologische Praxis

Straubing, , Germany

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Landesklinik Teupitz

Teupitz, , Germany

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Zentrum für Neurologie und Hertie-Institut für Klinische Hirnforschung

Tübingen, , Germany

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Klinikum Weiden

Weiden, , Germany

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Stiftung Deutsche Klinik für Diagnostik

Wiesbaden, , Germany

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Gemeinschaftspraxis für Neurologie

Wolfenbüttel, , Germany

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Klinikum Wuppertal

Wuppertal, , Germany

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Medizinisches Studienzentrum

Würzburg, , Germany

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Universitätsklinikum Würzburg

Würzburg, , Germany

Site Status

Paracelsus Klinik

Zwickau, , Germany

Site Status

Countries

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Austria Germany

References

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Hefter H, Benecke R, Erbguth F, Jost W, Reichel G, Wissel J. An open-label cohort study of the improvement of quality of life and pain in de novo cervical dystonia patients after injections with 500 U botulinum toxin A (Dysport). BMJ Open. 2013 Apr 18;3(4):e001853. doi: 10.1136/bmjopen-2012-001853. Print 2013.

Reference Type RESULT
PMID: 23604344 (View on PubMed)

Hefter H, Kupsch A, Mungersdorf M, Paus S, Stenner A, Jost W; Dysport Cervical Dystonia Study Group. A botulinum toxin A treatment algorithm for de novo management of torticollis and laterocollis. BMJ Open. 2011 Jan 1;1(2):e000196. doi: 10.1136/bmjopen-2011-000196.

Reference Type RESULT
PMID: 22021883 (View on PubMed)

Other Identifiers

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2004-002086-20

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

A-94-52120-098

Identifier Type: -

Identifier Source: org_study_id

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