Renal Resistive Index as an Indicator of Lupus Nephritis Severity and Systemic Lupus Activity

NCT ID: NCT06757725

Last Updated: 2025-01-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-03

Study Completion Date

2023-10-15

Brief Summary

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The study explores the role of the colour Doppler scanning of the renal arteries and its relation to the degree of disease affection in lupus nephritis

Detailed Description

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we have recruited patients into 3 groups The first group is patients with lupus nephritis The second groups is patients with systemic lupus erythromatosus without nephritis The third groups is normal healthy controls we explored the association of colour Doppler and the renal resistive index with the degree of the renal affection in lupus nephritis

Conditions

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Systemic Lupus Erthematosus Lupus Glomerulonephritis Lupus Flare

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Patients with lupus nephritis

Theses are 25 patients diagnosed with lupus nephritis

Group Type ACTIVE_COMPARATOR

colour doppler of the renal artery and measurement of resistive index

Intervention Type DIAGNOSTIC_TEST

using colour doppler to asses vascular resistance and resistive index

Lupus without nephritis

Theses are 25 patients diagnosed with lupus without evidence of nephritis

Group Type ACTIVE_COMPARATOR

colour doppler of the renal artery and measurement of resistive index

Intervention Type DIAGNOSTIC_TEST

using colour doppler to asses vascular resistance and resistive index

Healthy control

Patients who are healthy volunteers with no evidence of nephritis or systemic lupus

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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colour doppler of the renal artery and measurement of resistive index

using colour doppler to asses vascular resistance and resistive index

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* 1\. Systemic lupus erythematosus. 2. Lupus nephritis. 3. Adults \>18 years old.

Exclusion Criteria

* 1\. End Stage Renal Disease. 2. Diabetes Mellitus. 3. Heart failure. 4. Hepatic diseases. 5. Obstructive nephropathy. 6. Renal artery stenosis or occlusion.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Kasr El Aini Hospital

OTHER

Sponsor Role lead

Responsible Party

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Tarek Samy Abdelaziz

Associate professor of Internal medicine and nephrology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Cairo University Hospitals

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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MS-632-2022

Identifier Type: OTHER

Identifier Source: secondary_id

MS-632-2022

Identifier Type: -

Identifier Source: org_study_id

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