T Regulatory Cells IN LUPUS NEPHRITIS

NCT ID: NCT06428539

Last Updated: 2024-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

65 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-07-01

Study Completion Date

2025-08-01

Brief Summary

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* To study the role FoxP3-positive T regulatory cells in the pathogenesis of Lupus Nephritis, and determine the factors associated with levels of T regs .
* To compare the functional capacity of T regs in LN and in normal individuals.

Detailed Description

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Lupus Nephritis (LN) encompasses a group of glomerulonephrites, that occur in association with systemic lupus erythematosus (SLE). The mainstream theory that it is an immune disease resulting from loss of immune tolerance against body cells. The regulatory T cells (T regs ) are a subpopulation of immune cells that maintain tolerance to self-antigens and suppress autoimmune diseases. The main marker of Tregs is FoxP3 (forkhead box protein 3) positivity. Moreover, It has been suggested that functional capacity of Tregs is also compromised in autoimmune diseases. Studying the role of T regs in LN is a promising field that can help tailor current immune therapy and develop new treatment strategies.

Conditions

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Lupus Nephritis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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patients with active lupus nephritis

patients with active lupus nephritis as active urinary sediment, or rising renal chemistry

T-reg cells

Intervention Type DIAGNOSTIC_TEST

laboratory test

patients with lupus nephritis in remission

Patients who were previously active, but now in remission

T-reg cells

Intervention Type DIAGNOSTIC_TEST

laboratory test

normal individuals

normal healthy participants

T-reg cells

Intervention Type DIAGNOSTIC_TEST

laboratory test

Interventions

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T-reg cells

laboratory test

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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t regulatory cells

Eligibility Criteria

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Inclusion Criteria

adults both genders clinical diagnosis of lupus nephritis

Exclusion Criteria

patients diagnosed with other renal pathologies, e.g. diabetic kidney disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Mohamed AbdEllah Ahmed Hussein

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Mohamed AH Hussein

Role: CONTACT

+966554599271

References

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Doglio M, Alexander T, Del Papa N, Snowden JA, Greco R; Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT). New insights in systemic lupus erythematosus: From regulatory T cells to CAR-T-cell strategies. J Allergy Clin Immunol. 2022 Dec;150(6):1289-1301. doi: 10.1016/j.jaci.2022.08.003. Epub 2022 Sep 20.

Reference Type RESULT
PMID: 36137815 (View on PubMed)

Other Identifiers

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T cells in lupus LN

Identifier Type: -

Identifier Source: org_study_id

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