Outcomes of Isolated LCx Occlusion

NCT ID: NCT06750328

Last Updated: 2024-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-12-16

Study Completion Date

2027-11-12

Brief Summary

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To assess procedural success and short term clinical outcomes of primary PCI to isolated LCx acute occlusion.

Detailed Description

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ST-segment elevation myocardial infarction (STEMI) involving acute occlusion of the left circumflex (LCx) coronary artery represent only 14-21% of STEMIs

LCx acute occlusion may be difficult to be diagnosed . Only 50% of patients with LCx occlusion exhibited ST segment elevation during the acute phase, 38% showed no ST segment changes, while 15% presented with isolated ST segment depression This may lead to delay in transfer to cath lab, delay in reperfusion therapy and consequently loss of more myocytes and more major adverse cardiovascular events (MACE) .

Due to relative rare occurrence of isolated LCx coronary artery occlusion, little is known in literature about the clinical outcomes of isolated LCx occlusion , so we will conduct a retrospective observational study in our tertiary primary percutaneous coronary intervention (PCI) center to detect the incidence , procedural and clinical outcomes after 6 months of patients who had isolated LCx acute occlusion and underwent primary PCI.

Conditions

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LCx Occlusion STEMI STEMI

Keywords

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LCx occlusion STEMI

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Follow up after PPCI

To assess procedural success and short term clinical outcomes of primary PCI to isolated LCx acute

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients presented to Assiut University heart hospital with STEMI who underwent primary PCI that revealed isolated LCx acute occlusion (single culprit artery) between January 2018 to January 2025 will be included.

Exclusion Criteria

-Patients with cardiogenic shock, NYHA class III-IV and multivessel coronary artery disease will be excluded.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Esraa gamal mohammed

Resident doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Esraa Gamal Mohammed, Master student

Role: CONTACT

Phone: +2 01158863129

Email: [email protected]

References

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Geffin R, Triska J, Najjar S, Berman J, Cruse M, Birnbaum Y. Why do we keep missing left circumflex artery myocardial infarctions? J Electrocardiol. 2024 Mar-Apr;83:4-11. doi: 10.1016/j.jelectrocard.2023.12.011. Epub 2023 Dec 26.

Reference Type BACKGROUND
PMID: 38181483 (View on PubMed)

From AM, Best PJ, Lennon RJ, Rihal CS, Prasad A. Acute myocardial infarction due to left circumflex artery occlusion and significance of ST-segment elevation. Am J Cardiol. 2010 Oct 15;106(8):1081-5. doi: 10.1016/j.amjcard.2010.06.016.

Reference Type BACKGROUND
PMID: 20920642 (View on PubMed)

Stribling WK, Kontos MC, Abbate A, Cooke R, Vetrovec GW, Dai D, Honeycutt E, Wang TY, Lotun K. Left circumflex occlusion in acute myocardial infarction (from the National Cardiovascular Data Registry). Am J Cardiol. 2011 Oct 1;108(7):959-63. doi: 10.1016/j.amjcard.2011.05.027. Epub 2011 Aug 4.

Reference Type BACKGROUND
PMID: 21820644 (View on PubMed)

Other Identifiers

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LCx occlusion

Identifier Type: -

Identifier Source: org_study_id