Biomarkers in EV Associated With Marrow Adiposity in Anorexia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-05-15

Study Completion Date

2026-07-31

Brief Summary

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The aim of this observational study is to identify biomarkers in extracellular vesicles associated with medullary adiposity occurring in patients with anorexia nervosa. The main question it aims to answer is:

Can this medullary adiposity be associated with the bone deterioration observed in this population?

Participants will be assessed for body composition and a blood sample will be taken by non-invasive techniques.

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Detailed Description

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Conditions

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Anorexia Nervosa Restricting Type Anorexia Nervosa (DSM-IV Revised Criteria)

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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AN

Patients with Anorexia Nervosa diagnosed according to the DSM-V criteria.

No interventions assigned to this group

AN-R

Patients recovered from Anorexia Nervosa

No interventions assigned to this group

CON

Healthy subjects of the same age and gender as all other groups

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

For AN group:

* Diagnosis of active AN according to DSM-5 criteria
* BMI of less than 17kg/m2
* Present amenorrhoea in the 3 months prior to the start of the study.

For AN-R group:

* Achieved weight gain of more than 85%.
* Normal menstruation in the last 3 months.

For Control group:

* Population of the same age and gender as the AN and AN-R groups.
* If pubertal population, presenting a chronological age of ± 2 years.
* Normal menstruation
* Normal BMI (\>18.5 kg/m2)
* No presence of previous dietary transtrons.

Exclusion Criteria

* Not receiving oestrogens, contraceptives or glucocorticoids in the 3 months prior to the start of the study.
* Not to suffer from chronic diseases, such as diabetes, pathologies affecting the bone system or thyroid function.
* Do not take calcium or vitamin supplements.

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes