Advanced Wireless Sensors for Neonatal Care in the Delivery Room

NCT ID: NCT06693817

Last Updated: 2025-04-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

600 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-08

Study Completion Date

2027-06-30

Brief Summary

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The goals of this observational study is to assess whether a new advanced wireless skin sensor vital sign monitoring system can effectively monitor the vital signs of healthy newborn infants (≥ 35 weeks gestational age). The main aims of this Study are to:

1. Assess feasibility
2. Evaluate safety
3. Determine accuracy of the wireless monitoring system, compared to the standard of care wired vital sign monitoring system, immediately after delivery and for the first 2h of age in the obstetrical center under unsupervised parents' care. The newborn infants participating in the Study will have both vital sign monitoring systems placed on their chest and limb. Their vital signs will be monitored for 2h consecutively.

Detailed Description

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When the transition from intrauterine to extrauterine life necessitates Neonatal Resuscitation, specialized monitoring of vital signs is required. Sudden Unexpected Postnatal Collapse (SUPC) is an apnea or cardiorespiratory failure occurring in otherwise healthy near-term or term neonates, usually in the first 48 hours of age, during the initial Kangaroo Mother Care (KMC) in the obstetrical center. SUPC carries a high morbidity and mortality rate. Approximately 10 million babies do not breathe immediately after birth, and 60% require basic resuscitation interventions. Sudden Unexpected Postnatal Collapse has been estimated to occur in 2.6-133 cases per 100.000 newborns and over 50% of the cases occur following accidental suffocation, which frequently goes unrecognised by parents in the obstetrical center during unsupervised KMC.

Current guidelines recommend monitoring of heart rate (HR), oxygen saturation (SpO2), and skin temperature (Tskin) during neonatal resuscitation. This is usually achieved by using wired electrodes and sensors that require expensive and large base units attached to a power supply. SUPC is a rare but largely preventable cause of neonatal mortality that deserves particular attention. Better resuscitation and prevention of SUPC might be achieved by continuous non-intrusive monitoring of vital signs immediately after delivery and while in the obstetrical center.

This research will address a very important gap in care; the need for safe and accurate advanced, non-invasive, and non-intrusive wireless technologies for monitoring of vital signs immediately after birth and during the immediate postnatal care, potentially preventing cases of SUPC while in the obstetrical center.

Reliable and low-cost wireless monitoring that could be used immediately after delivery would promote widespread adoption of neonatal resuscitation recommendations in low and middle income countries, improve detection of vital signs quickly after delivery and during early unsupervised KMC, and optimize neonatal care in the obstetrical centers or during hospital stay, to prevent cases of SUPC and its associated high mortality.

Conditions

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Sudden Unexplained Infant Death Apnea of Newborn Newborn Morbidity Newborn Asphyxia Birth Outcome, Adverse Birth Asphyxia Pregnancy Related Newborn; Vitality ECG Electrode Site Reaction Infant ALL Infant Death Infant, Newborn, Diseases Infant Apnea Infant Conditions Parents Delivery Problem for Fetus Delivery Complication

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Vaginal Birth

Wireless monitoring system placed first for vaginal birth. 15-20 minutes later, the wired monitoring system is placed. Both systems stay in place for 2 hours.

Group Type OTHER

Wireless skin sensors vital sign monitoring system

Intervention Type DEVICE

The wireless monitoring system will be applied to the newborn and consist of a chest sensor (Anne Arc by Sibel Inc.) and a RAD-7 (Masimo)pulse oximeter limb sensor.

Wired vital sign monitoring system

Intervention Type DEVICE

A standard ECG and SpO2 monitoring device will be applied suing the Infinity M540 monitor (Draeger, Germany). The chest sensor will be placed as per standard of care on the newborn's chest and abdomen, and the SpO2 sensor on their hands or feet.

C-Section Birth

System placement randomized for C-section. One system placed first and the alternate placed immediately after. Both systems stay in place for 2 hours.

Group Type OTHER

Wireless skin sensors vital sign monitoring system

Intervention Type DEVICE

The wireless monitoring system will be applied to the newborn and consist of a chest sensor (Anne Arc by Sibel Inc.) and a RAD-7 (Masimo)pulse oximeter limb sensor.

Wired vital sign monitoring system

Intervention Type DEVICE

A standard ECG and SpO2 monitoring device will be applied suing the Infinity M540 monitor (Draeger, Germany). The chest sensor will be placed as per standard of care on the newborn's chest and abdomen, and the SpO2 sensor on their hands or feet.

Interventions

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Wireless skin sensors vital sign monitoring system

The wireless monitoring system will be applied to the newborn and consist of a chest sensor (Anne Arc by Sibel Inc.) and a RAD-7 (Masimo)pulse oximeter limb sensor.

Intervention Type DEVICE

Wired vital sign monitoring system

A standard ECG and SpO2 monitoring device will be applied suing the Infinity M540 monitor (Draeger, Germany). The chest sensor will be placed as per standard of care on the newborn's chest and abdomen, and the SpO2 sensor on their hands or feet.

Intervention Type DEVICE

Other Intervention Names

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Anne Arc (Sibel Health Inc) Radical-7 (Masimo) Infinity M540 (Draeger)

Eligibility Criteria

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Inclusion Criteria

1. Newborns ≥35 weeks (gestational age)
2. Newborns determined to be clinically stable at delivery
3. Newborns with no skin abnormalities

Exclusion Criteria

1. Newborns ≤ 35 weeks (gestational age)
2. Newborns determined to not be clinically stable at delivery
3. Newborns with Skin abnormalities
Minimum Eligible Age

35 Weeks

Maximum Eligible Age

42 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Federal University of Uberlandia

OTHER

Sponsor Role collaborator

University of Campinas, Brazil

OTHER

Sponsor Role collaborator

Sanatorio de la Trinidad Palermo

UNKNOWN

Sponsor Role collaborator

Mbuya Nehanda Hospital Harare Zimbabwe

UNKNOWN

Sponsor Role collaborator

Hopsital Central de Maputo, Mozambique

UNKNOWN

Sponsor Role collaborator

Guilherme Sant'Anna, MD

OTHER

Sponsor Role lead

Responsible Party

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Guilherme Sant'Anna, MD

Senior Clinician Scientist, Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Guilherme Sant'Anna, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

The Research institute of the McGill University Health Centre

Locations

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Hospitals Sanatorio Trinidad Palermo

Buenos Aires, , Argentina

Site Status NOT_YET_RECRUITING

Hospital de Clínicas de Uberlândia

Umuarama, Minas Gerais, Brazil

Site Status NOT_YET_RECRUITING

ii. Hospital da Mulher Jose Aristodemo Pinotti State University of Campinas -CAISM

São Paulo, , Brazil

Site Status NOT_YET_RECRUITING

Montreal Children's Hospital

Montreal, Quebec, Canada

Site Status RECRUITING

Royal Victoria Hospital

Montreal, Quebec, Canada

Site Status RECRUITING

Maputo Central Hospital

Maputo, , Mozambique

Site Status NOT_YET_RECRUITING

Mbuya Nehanda Hospital

Harare, , Zimbabwe

Site Status NOT_YET_RECRUITING

Countries

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Argentina Brazil Canada Mozambique Zimbabwe

Central Contacts

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Guilherme Sant´Anna, MD, PhD

Role: CONTACT

514-934-1934 ext. 27049

Alyssa Maximov, BSc

Role: CONTACT

514-934-1934 ext. 78229

Facility Contacts

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Nestor Vain, MD

Role: primary

Daniela Marques, MD

Role: primary

Sergio Chagas, MD, PhD

Role: primary

Guilherme Sant'Anna, MD

Role: primary

1-514-412-4400 ext. 23489

Guilherme Sant'Anna, MD, PhD

Role: primary

Sonia Bandeira, MD

Role: primary

Alex Stevenson, MBChB, MMed, Mphil

Role: primary

Other Identifiers

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AWARD Study

Identifier Type: -

Identifier Source: org_study_id

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