Preliminary Study to the Conception of a Non-invasive Neonatal Monitoring System With Development of a Database

NCT ID: NCT02863978

Last Updated: 2022-12-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

746 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-11-08

Study Completion Date

2024-06-10

Brief Summary

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Each year, 300 000 new borns are hospitalised in neonatology units in Europe. This period is very sensitive as newborns are exposed to a high risk of morbidity and mortality, with severe impact on neuro-developmental prognostic. The Rennes University Hospital was granted a specific funding from the European Union in the framework of the Horizon 2020 programme (Call PERSONALISING HEALTH AND CARE 2015-single-stage - Grant Agreement Number 689260) to develop the Digi-NewB project. This project aims to develop innovative non-invasive monitoring tools to support decision making in health. Such tools include a new generation of real time monitoring in neonatology using composite indices made of cardio-respiratory variables, movements, sounds, and clinical data. The Digi-NewB cohort aims to gather all physiological data relevant for the creation of the composite indices.

Detailed Description

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The database will be used to answer the following specific objectives, with priority given to the two first ones (sepsis and maturation) :

1. Early diagnosis of sepsis for the following cases : Late onset sepsis of premature newborns, materno-fœtal sepsis, and newborn infection by chorioamnionitis
2. Cardio-respiratory and neurobehavioral maturation (movements, sleeping cycles)
3. Influence of environmental factors and developmental care on selected parameters
4. Influence on care organisation of the possibility to access videos and movement analyses by medical teams
5. Influence of glycemia on selected parameters
6. Influence of neurological lesions and broncho-pulmonary dysplasia on selected parameters
7. Indices correlation with medical images MRI (T1, T2, diffusion, Arterial Spin Labelling) from neonatal units and with health evaluated after 1 and 2 years with the Ages \& Stages Questionnaires (ASQ)
8. Evaluation of the acquisition system's user-friendliness

Conditions

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Infant, Premature

Keywords

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Sepsis Neonates Cardio-respiratory maturation Neurobehavioral maturation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Digi-NewB Cohort

Multimodal signal acquisitions

Group Type EXPERIMENTAL

Multimodal signal acquisitions

Intervention Type OTHER

Cardiac and respiratory signals are collected from the clinical monitoring routinely gathered in hospital neonatal units.

Movement quantification and baby's sounds are extracted thanks to a dedicated system which will collect images and sound with microphones and cameras.

Interventions

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Multimodal signal acquisitions

Cardiac and respiratory signals are collected from the clinical monitoring routinely gathered in hospital neonatal units.

Movement quantification and baby's sounds are extracted thanks to a dedicated system which will collect images and sound with microphones and cameras.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Newborn hospitalised in the neonatology services of participating hospitals
* One of the legal representatives gave its signed agreement to take part to the study
* New born aged of less than 6 weeks in corrected term

Exclusion Criteria

* No signed agreement from the legal representative
Maximum Eligible Age

6 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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European Union

OTHER

Sponsor Role collaborator

GCS Hôpitaux Universitaires Grand-Ouest

UNKNOWN

Sponsor Role collaborator

Rennes 1 University

UNKNOWN

Sponsor Role collaborator

Tampere University of Technology

OTHER

Sponsor Role collaborator

Voxygen Health

UNKNOWN

Sponsor Role collaborator

INESC TEC Porto

UNKNOWN

Sponsor Role collaborator

National University of Ireland, Galway, Ireland

OTHER

Sponsor Role collaborator

Synchrophi Systems Ltd

UNKNOWN

Sponsor Role collaborator

Rennes University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Patrick PLADYS, MD, PhD

Role: STUDY_DIRECTOR

CHU Rennes

Locations

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Brest University Hospital

Brest, Brittany Region, France

Site Status

Angers University Hospital

Angers, , France

Site Status

Nantes University Hospital

Nantes, , France

Site Status

Poitiers University Hospital

Poitiers, , France

Site Status

Rennes University Hospital

Rennes, , France

Site Status

Tours University Hospital

Tours, , France

Site Status

Countries

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France

Related Links

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Other Identifiers

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2016-A00993-48

Identifier Type: OTHER

Identifier Source: secondary_id

35RC16_9714

Identifier Type: -

Identifier Source: org_study_id