Orofacial Functions in Individuals With and Without Molar Incisor Hypomineralization

NCT ID: NCT06692257

Last Updated: 2024-11-18

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 56 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-03-01
• Study Completion Date: 2025-11-01

Brief Summary

Molar incisor hypomineralization (MIH) is a qualitative developmental defect of the enamel with a complex, multifactorial nature and a significant genetic component that predominantly affects the permanent first molars and, occasionally, the permanent incisors. Individuals with MIH have a compromised stomatognathic system manifested by muscle hyperactivity under postural and dynamic conditions. However, there is a gap in knowledge on the specific functional abnormalities that these individuals experience. Early identification and intervention, with a focus on the prevention of orofacial dysfunctions and deviations in facial growth and development, are aspects of the utmost importance. Therefore, the aim of the proposed study is to perform a comparative analysis of orofacial functions with an emphasis on breathing and chewing patterns in individuals with and without MIH. Methods and Analysis: Assessments will be performed using the Nordic Orofacial Test - Screening (NOT-S). Descriptive statistics will be performed and comparisons will be made using the chi-square test, adopting a 5% significance level.

Conditions

Molar Hypomineralization, Incisor

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Individuals without MIH

All permanent molars without indices compatible with MIH

Observation

Intervention Type: BEHAVIORAL

To perform a comparative analysis of orofacial functions with an emphasis on breathing and chewing patterns in individuals with and without MIH.

Individuals with MIH

At least one permanent molar with indices compatible with MIH (code 2, 21, 22 and 3 - Ghanim criteria)

Observation

Intervention Type: BEHAVIORAL

To perform a comparative analysis of orofacial functions with an emphasis on breathing and chewing patterns in individuals with and without MIH.

Interventions

Observation

To perform a comparative analysis of orofacial functions with an emphasis on breathing and chewing patterns in individuals with and without MIH.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Children 6 to 12 years of age with a complete mixed dentition with all first molars present and in occlusion;
• Having all first molars erupted, without caries or previous treatment;

Exclusion Criteria

• Children with amelogenesis and dentinogenesis imperfecta;
• Children undergoing orthodontic treatment;
• Children with a genetic syndrome;
• Children with the premature loss of deciduous teeth;
• Children with acute respiratory problems;
• Children in treatment.

• Minimum Eligible Age: 6 Years
• Maximum Eligible Age: 12 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Nove de Julho

OTHER

Sponsor Role: lead

Responsible Party

Sandra Kalil Bussadori

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

References

Pernomiam FC, Mandetta ARH, Ribeiro CDPV, Camargo CCB, Romano IMF, Sobral APT, Mesquita-Ferrari RA, Fernandes KPS, Horliana ACRT, Duran CCG, Motta LJ, Bussadori SK. Orofacial functions with emphasis on breathing and chewing patterns in individuals with and without molar incisor hypomineralisation: observational study protocol conducted in a dental clinic in Brazil. BMJ Open. 2025 Jun 4;15(6):e101725. doi: 10.1136/bmjopen-2025-101725.

Reference Type: DERIVED

PMID: 40467310 (View on PubMed)

Other Identifiers

Orofacial functions

Identifier Type: -

Identifier Source: org_study_id