Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease
NCT ID: NCT06688968
Last Updated: 2025-03-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
120 participants
INTERVENTIONAL
2025-02-04
2025-12-01
Brief Summary
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The main questions it aims to answer are:
1. The description of different profiles of musical engagement in early-stage AD, in PD and in healthy elderly subjects.
2. The extent of executive, mnestic and hedonic dysfunctions will impact differently on emotional engagement, autobiographical evocation and sensitivity to musical reward, and will therefore enable distinct profiles to be drawn up.
Participants will have an intervention consisting of an interview with a neuropsychologist lasting approximately 2 hours, including :
* A semi-structured interview to check the participants eligibility and gather demographic data.
* Neuropsychological tests and questionnaires will then be administered.
* A relative of the study participant will help complete questionnaires.
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Detailed Description
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To date, no study has investigated the evolution of sensitivity to musical reward in AD. Furthermore, no study has discriminated the evolution of musical engagement in several neurodegenerative pathologies.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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patient with early-onset Alzheimer's disease (AD)
patients followed up at the Centre Mémoire de Ressources et de Recherche (CMRR) of Montpellier, over 60 with Alzheimer's disease who have cognitive impairment based on an MMSE (Mini Mental State Examination) ≥ 20 and live at home with a relative
neuropsychologist interview
It will take place either at the hospital or at the participant's home.
This interview will consist of :
* socio-demographic data collection
* neuropsychological tests:
* MMSE test (Mini Mental State Examination) cognitive function
* RL-RI-16 test (16-item free recall/indexed recall test)
* BECS test (Semantic knowledge assessment battery )
* WCST test (Wisconsin Card Sorting Test )
* Musical Cognition Test
* Help from the participant's relative to answer certain questions, in particular the MuseEQ-24 questionnaire
questionnaire
The participant answers questionnaires:
* Questionnaire MusEQ-24 self reported (Music Engagement Questionnaire)
* Questionnaire BMRQ (Barcelona Reward Music Questionnaire)
* Questionnaire SHAPS (Snaith-Hamilton Pleasure Scale)
* Questionnaire LARS (Lille's Apathy Rating Scale)
* Questionnaire PHQ-9 (Patient Health Questionnaire 9 items)
patients with parkinson's disease (PD)
patients followed up at the Center Expert Parkinson of Montpellier (CEPMo), over 60 with Parkinson's disease who have cognitive impairment based on an MMSE (Mini Mental State Examination) ≥ 20 and live at home with a relative
neuropsychologist interview
It will take place either at the hospital or at the participant's home.
This interview will consist of :
* socio-demographic data collection
* neuropsychological tests:
* MMSE test (Mini Mental State Examination) cognitive function
* RL-RI-16 test (16-item free recall/indexed recall test)
* BECS test (Semantic knowledge assessment battery )
* WCST test (Wisconsin Card Sorting Test )
* Musical Cognition Test
* Help from the participant's relative to answer certain questions, in particular the MuseEQ-24 questionnaire
questionnaire
The participant answers questionnaires:
* Questionnaire MusEQ-24 self reported (Music Engagement Questionnaire)
* Questionnaire BMRQ (Barcelona Reward Music Questionnaire)
* Questionnaire SHAPS (Snaith-Hamilton Pleasure Scale)
* Questionnaire LARS (Lille's Apathy Rating Scale)
* Questionnaire PHQ-9 (Patient Health Questionnaire 9 items)
Healthy control
Subjects aged over 60, with no known neurodegenerative disease, living at home with a relative in the Hérault département.
neuropsychologist interview
It will take place either at the hospital or at the participant's home.
This interview will consist of :
* socio-demographic data collection
* neuropsychological tests:
* MMSE test (Mini Mental State Examination) cognitive function
* RL-RI-16 test (16-item free recall/indexed recall test)
* BECS test (Semantic knowledge assessment battery )
* WCST test (Wisconsin Card Sorting Test )
* Musical Cognition Test
* Help from the participant's relative to answer certain questions, in particular the MuseEQ-24 questionnaire
questionnaire
The participant answers questionnaires:
* Questionnaire MusEQ-24 self reported (Music Engagement Questionnaire)
* Questionnaire BMRQ (Barcelona Reward Music Questionnaire)
* Questionnaire SHAPS (Snaith-Hamilton Pleasure Scale)
* Questionnaire LARS (Lille's Apathy Rating Scale)
* Questionnaire PHQ-9 (Patient Health Questionnaire 9 items)
Interventions
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neuropsychologist interview
It will take place either at the hospital or at the participant's home.
This interview will consist of :
* socio-demographic data collection
* neuropsychological tests:
* MMSE test (Mini Mental State Examination) cognitive function
* RL-RI-16 test (16-item free recall/indexed recall test)
* BECS test (Semantic knowledge assessment battery )
* WCST test (Wisconsin Card Sorting Test )
* Musical Cognition Test
* Help from the participant's relative to answer certain questions, in particular the MuseEQ-24 questionnaire
questionnaire
The participant answers questionnaires:
* Questionnaire MusEQ-24 self reported (Music Engagement Questionnaire)
* Questionnaire BMRQ (Barcelona Reward Music Questionnaire)
* Questionnaire SHAPS (Snaith-Hamilton Pleasure Scale)
* Questionnaire LARS (Lille's Apathy Rating Scale)
* Questionnaire PHQ-9 (Patient Health Questionnaire 9 items)
Eligibility Criteria
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Inclusion Criteria
* French-speaking and volunteering for the study
* Living at home with a relative
* Biological diagnosis of probable Alzheimer's disease according to NINCDS-ADRDA criteria (McKhann et al., 1984)
* MMSE greater than or equal to 20
* Diagnosis of Idiopathic Parkinson's disease
* MMSE greater than or equal to 20
Exclusion Criteria
* Autistic disorders
* History of stroke or head trauma
* Unstable medical condition (cancer)
* Subject unable to read and/or write
* Hearing impairment without hearing aids
* Refusal of consent after information
* Persons unable to give consent, research carried out in emergency situations, etc.)
* Non-affiliation with a social security scheme
* Person deprived of liberty (by judicial or administrative decision, or forced hospitalization)
* Person under legal protection (guardianship, curatorship, legal protection)
* Person participating in another research project with an exclusion period still in progress
60 Years
ALL
Yes
Sponsors
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Laboratoire EPSYLON
UNKNOWN
University Hospital, Montpellier
OTHER
Responsible Party
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Principal Investigators
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KARIM BENNYS, MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Montpellier
Locations
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Montpellier Seniors' Association
Montpellier, Hérault, France
CHU de Montpellier - CEPMo
Montpellier, Hérault, France
CHU de Montpellier - CMRR
Montpellier, Hérault, France
Countries
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Central Contacts
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Facility Contacts
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References
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Bian X, Wang Y, Zhao X, Zhang Z, Ding C. Does music therapy affect the global cognitive function of patients with dementia? A meta-analysis. NeuroRehabilitation. 2021;48(4):553-562. doi: 10.3233/NRE-210018.
Zhang Y, Cai J, An L, Hui F, Ren T, Ma H, Zhao Q. Does music therapy enhance behavioral and cognitive function in elderly dementia patients? A systematic review and meta-analysis. Ageing Res Rev. 2017 May;35:1-11. doi: 10.1016/j.arr.2016.12.003. Epub 2016 Dec 23.
van der Steen JT, van Soest-Poortvliet MC, van der Wouden JC, Bruinsma MS, Scholten RJ, Vink AC. Music-based therapeutic interventions for people with dementia. Cochrane Database Syst Rev. 2017 May 2;5(5):CD003477. doi: 10.1002/14651858.CD003477.pub3.
Platel H, Eustache ML, Coppalle R, Viard A, Eustache F, Groussard M, Desgranges B. Boosting Autobiographical Memory and the Sense of Identity of Alzheimer Patients Through Repeated Reminiscence Workshops? Front Psychol. 2021 Feb 15;12:636028. doi: 10.3389/fpsyg.2021.636028. eCollection 2021.
Morris IB, Vasudevan E, Schedel M, Weymouth D, Loomis J, Pinkhasov T, Muratori LM. Music to One's Ears: Familiarity and Music Engagement in People With Parkinson's Disease. Front Neurosci. 2019 Jun 25;13:661. doi: 10.3389/fnins.2019.00661. eCollection 2019.
Machado Sotomayor MJ, Arufe-Giraldez V, Ruiz-Rico G, Navarro-Paton R. Music Therapy and Parkinson's Disease: A Systematic Review from 2015-2020. Int J Environ Res Public Health. 2021 Nov 4;18(21):11618. doi: 10.3390/ijerph182111618.
Loas G, Duru C, Godefroy O, Krystkowiak P. Hedonic deficits in Parkinson's disease: is consummatory anhedonia specific? Front Neurol. 2014 Mar 10;5:24. doi: 10.3389/fneur.2014.00024. eCollection 2014.
Groussard M, Chan TG, Coppalle R, Platel H. Preservation of Musical Memory Throughout the Progression of Alzheimer's Disease? Toward a Reconciliation of Theoretical, Clinical, and Neuroimaging Evidence. J Alzheimers Dis. 2019;68(3):857-883. doi: 10.3233/JAD-180474.
Belfi AM, Moreno GL, Gugliano M, Neill C. Musical reward across the lifespan. Aging Ment Health. 2022 May;26(5):932-939. doi: 10.1080/13607863.2021.1871881. Epub 2021 Jan 14.
Other Identifiers
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RECHMPL23_0427
Identifier Type: -
Identifier Source: org_study_id
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