Beneficial Effects of Music on Cognition and Consciousness Level

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

86 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-06-25

Study Completion Date

2019-10-23

Brief Summary

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Exposure to music improves cognitive function in 'healthy' participants and in brain-damaged patients. However, it is still difficult to understand what precisely in music causes a positive effect : are they emotional components, familiarity or preference which improve cognition or is there any specific effect of music? Moreover, it is not yet possible to characterize the neural and functional links between the brain systems solicited by music and those associated with other cognitive functions enhanced by music.

Finally, researches on brain-damaged patients have not exploited the potential effect of music on the level of alert and perceptual awareness, while this type of stimulation could be a valuable tool to improve cognition in patients with a disturbance of consciousness and alertness.

The main objective is to describe the impact of music on the brain's response to self-referential or neutral stimuli in brain-damaged patients with persistent consciousness disorder after a coma and in healthy participants.

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Detailed Description

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Conditions

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Coma

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Brain-damaged patients

Electroencephalography (EEG) will be performed in patients in coma, in a vegetative state or in a minimally conscious state to assess the P300 response after different auditive stimulations

Group Type EXPERIMENTAL

Electroencephalography (EEG)

Intervention Type OTHER

EEG will be performed to assess brain activity in response to sounds of different nature, including music and the given name of the registered person

Healthy volunteers

Electroencephalography (EEG) will be performed in healthy participants to assess the P300 response and medial prefrontal cortex activity after different auditive stimulations

Group Type ACTIVE_COMPARATOR

Electroencephalography (EEG)

Intervention Type OTHER

EEG will be performed to assess brain activity in response to sounds of different nature, including music and the given name of the registered person

Interventions

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Electroencephalography (EEG)

EEG will be performed to assess brain activity in response to sounds of different nature, including music and the given name of the registered person

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Disorders of consciousness (Traumatic brain injury, stroke or anoxic encephalopathy)
* Coma diagnosis (Plum and Posner, 1966), vegetative state (Task Force, 1994) or minimally conscious state (Giacino, Ashwal et al. 2002)
* Lack of autonomic crisis since one week minimum
* Medical condition considered stable
* Patients who do not present hearing loss. Peaks I and II of Brainstem Auditory Evoked Potentials (BAEP) will be normal.

* Subjects with normal hearing
* Absence of neurological disorder
* Subjects able to understand the experimental instructions

Exclusion Criteria

* Hearing Problem
* Uncontrolled Epilepsy
* Autonomic crises
* Medical unstable state
* Pregnant or likely to be (interrogation data) or breastfeeding woman

Healthy participants :

* Hearing problems and / or hearing loss higher than 30 decibels Hearing Level (dB HL) at a frequency band from 250 to 8000 Hz
* Neurological disorders
* Pregnant or likely to be (interrogation data) or breastfeeding woman

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes