Lexical Priming by Music in Alzheimer's Disease and Healthy Aging

NCT ID: NCT03342326

Last Updated: 2020-09-11

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 58 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-04-03
• Study Completion Date: 2019-05-29

Brief Summary

While verbal memory is quickly reached in the wake of Alzheimer's disease, the musical memory remains preserved until a late stage of the disease. This observation encouraged the development of music-based therapies in the management of neurocognitive and behavioral disorders that characterize Alzheimer's disease. In order to develop rehabilitation programs that effectively target cognitive functions to stimulate, it is necessary to understand the mechanisms underlying this beneficial effect of music on cognition.

Detailed Description

The investigators study the stimulation by the song, material integrating language and music, and having an autobiographical value. The investigators measure the lexical priming capacity of the song, that is, its ability to activate and maintain lexical and semantic representations, which are threatened with alteration in the course of the disease.

This lexical priming effect by song is measured in patients with mild Alzheimer's disease and healthy volunteers during a single test session. In the first phase of the session, participants are exposed to familiar songs, presented in sung, spoken or instrumental form, whose popularity they evaluate. In the second phase, they perform two implicit memory tasks: a trigram completion task and a lexical decision task. These tests measure the facilitation of the processing of words evoked by songs in relation to words unrelated to songs, reflecting a "long-term" memory update of mnemic traces of primed words.

Conditions

Alzheimer Disease

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

patient with Alzheimer's Disease

1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5.

2. Music Experience Questionnaire : questions about the past music training

3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not.

Group Type: OTHER

Exposure to familiar songs

Intervention Type: OTHER

3 conditions : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5.

Music Experience Questionnaire

Intervention Type: OTHER

questions about the past music training

Implicit tasks memory

Intervention Type: OTHER

2 tests : a) Completion of trigrams : freely complete the first 3 letters of a word.

b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not.

healthy volunteer

1. Exposure to familiar songs : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5.

2. Music Experience Questionnaire : questions about the past music training

3. Implicit tasks memory : a) Completion of trigrams : freely complete the first 3 letters of a word. b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not.

4. For volunteer over 65 years : Mini Mental State Examination, 5 words by Dubois and fluence verbal test

Group Type: OTHER

Exposure to familiar songs

Intervention Type: OTHER

3 conditions : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5.

Music Experience Questionnaire

Intervention Type: OTHER

questions about the past music training

Implicit tasks memory

Intervention Type: OTHER

2 tests : a) Completion of trigrams : freely complete the first 3 letters of a word.

b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not.

Questionnaires

Intervention Type: OTHER

Mini Mental State Examination, 5 words by Dubois and fluence verbal test

Interventions

Exposure to familiar songs

3 conditions : a) Words and Music (sing condition), b) Words only (spoken condition) and c) Music only (instrumental condition) After each song : rate the popularity of the song on a scale of 1 to 5.

Intervention Type: OTHER

Music Experience Questionnaire

questions about the past music training

Intervention Type: OTHER

Implicit tasks memory

2 tests : a) Completion of trigrams : freely complete the first 3 letters of a word.

b) lexical decision : judge whether an audibly presented sound sequence is a word existing in the French language or not.

Intervention Type: OTHER

Questionnaires

Mini Mental State Examination, 5 words by Dubois and fluence verbal test

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Presence of diagnostic criteria for Alzheimer's disease
• Age ≥ 65 years
• MMSE (Mini-mental state Examination) ≥ 20

• Age ≥ 18 years
• Absence of neurological or psychiatric antecedents
• For those aged 65 or over: MMSE (Mini-mental state Examination) greater than or equal to 27; non-pathological performance against the 5 words of Dubois and the verbal fluency test.

Exclusion Criteria

• Unstable clinical presentation or language presentation in the foreground
• Cognitive disorder of etiology different from that of Alzheimer's disease

• Visual or auditory disorders insufficiently corrected
• Oral or written expression in French insufficient to carry out tests
• Consumption of psychotropic drugs not stabilized

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Centre Hospitalier Universitaire de Saint Etienne

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

CHU de Saint Etienne

Saint-Etienne, , France

Countries

France

Other Identifiers

2017-A02686-47

Identifier Type: OTHER

Identifier Source: secondary_id

1708117

Identifier Type: -

Identifier Source: org_study_id