QLESP Block Versus Periarticular Infiltration for Postoperative Analgesia in Hip Surgery

NCT ID: NCT06688136

Last Updated: 2025-09-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 68 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-11-18
• Study Completion Date: 2025-09-05

Brief Summary

Local and/or regional analgesia techniques are critical components of an optimal multimodal analgesia technique, as they have been shown to improve pain relief as well as reduce opioid requirements. Optimal pain management technique balances pain relief with concerns about safety and adverse effects associated with analgesic techniques. Periarticular infiltration (PAI) is increasingly included as a component of multimodal analgesia technique for patients undergoing THA, as it provides improved postoperative pain relief with no effects on quadriceps function. Recently, our group has developed a novel transmuscular quadratus lumborum and modified erector spinae plane (QLESP) block, which is characterized by simple operation, high efficiency, and wide dermatomal coverage of sensory block. Therefore, we designed a randomized controlled trial to compare ultrasound-guided QLESP with PAI as a component of non-opioid analgesic regimen in patients undergoing THA via posterior approach. We hypothesized that QLESP would provide superior analgesia when compared with PAI. The primary outcome of the study was postoperative opioid requirements within the initial 24-h postoperative period after THA. The secondary objectives were to compare pain scores, postoperative quadriceps strength, the time to first rescue analgesia, opioid-related adverse effects, time to ambulation, and the time to hospital discharge.

Conditions

Regional Anaesthesia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: SINGLE

Study Groups

transmuscular quadratus lumborum and modified erector spinae plane (QLESP) block

Twenty ml of 0.4% ropivacaine was administered between the erector spinae muscle and the transverse process. Twenty ml of 0.4% ropivacaine was subsequently given between the quadratus lumborum and the psoas major muscles.

Group Type: EXPERIMENTAL

ropivacaine

Intervention Type: DRUG

Ropivacaine 200 mg diluted to 50 mL

Infiltration

Periarticular infiltration of 40 ml of 0.4% ropivacaine prior to closing the incision

Group Type: ACTIVE_COMPARATOR

ropivacaine

Intervention Type: DRUG

Ropivacaine 200 mg diluted to 50 mL

Interventions

ropivacaine

Ropivacaine 200 mg diluted to 50 mL

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Age 18-65 yrs

2. American Society of Anesthesiologists classification 1-3

3. Body mass index between 20 and 35 (kg/m2)

4. Undergo elective primary unilateral THA via a posterolateral approach

5. Informed consent

Exclusion Criteria

1. A known allergy to the drugs being used

2. Pre-existing neuropsychiatric disorders or language barrier

3. Analgesics intake, history of substance abuse

4. Contraindications to peripheral nerve block

5. Acute cerebrovascular disease

6. Severe liver failure

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Huazhong University of Science and Technology

OTHER

Sponsor Role: lead

Responsible Party

Xi Wu

Huazhong University of Science and Technology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Xi Wu

Role: PRINCIPAL_INVESTIGATOR

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Locations

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

Countries

China

Other Identifiers

WHUH20241101

Identifier Type: -

Identifier Source: org_study_id