Pericapsular Nerve Group (PENG) Block Combined With Periarticular Multimodal Drug Injection (PMDI) Versus Isolated PMDI for Pain Management After Total Hip Arthroplasty: a Randomized Controlled Trial

NCT ID: NCT05320913

Last Updated: 2022-05-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

58 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-04-04

Study Completion Date

2023-12-13

Brief Summary

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Adequate pain control after total hip arthroplasty is crucial for early ambulation and patient satisfaction. However, there is no consensus about optimal pain control after post operation. In general, the periarticular multimodal durg injection block has been done for pain control in primary total hip arthroplasty. The pericapsular nerve group (PENG) block has been recently introduced a new technique for blockade of the articular branches of the femoral, obturator and accessory obturator nerves. PENG block is possible to provide sufficient analgesia and preserve lower limb muscle strength. The investigators will compare PENG and PMDI block with isolated PMDI block in patients undergoing total hip arthroplasty.

Detailed Description

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Conditions

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Total Hip Arthroplasty, Postoperative Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Pericapsular nerve group(PENG) block combined with periarticular multimodal drug injection (PMDI)

Participants receiving pericapsular nerve group(PENG) block combined with periarticular multimodal drug injection (PMDI)

Group Type EXPERIMENTAL

Pericapsular nerve group(PENG) block combined with periarticular multimodal drug injection (PMDI)

Intervention Type PROCEDURE

periarticular local anesthetic infiltration with 120 mg of ropivacaine, epinephrine 0.2 mg and 30 mg of ketorolac diluted with normal saline to a total volume of 40 mL. + PENG block with ropivacaine 40 mg and epinephrine 0.1 mg with normal saline to a total volume of 20 mL

isolated periarticular multimodal drug injection (PMDI)

Arm Description: Participants receiving isolated periarticular multimodal drug injection (PMDI)

Group Type ACTIVE_COMPARATOR

isolated periarticular multimodal drug injection (PMDI)

Intervention Type PROCEDURE

periarticular local anesthetic infiltration with 150 mg of ropivacaine, epinephrine 0.3 mg and 30 mg of ketorolac diluted with normal saline to a total volume of 50 mL

Interventions

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Pericapsular nerve group(PENG) block combined with periarticular multimodal drug injection (PMDI)

periarticular local anesthetic infiltration with 120 mg of ropivacaine, epinephrine 0.2 mg and 30 mg of ketorolac diluted with normal saline to a total volume of 40 mL. + PENG block with ropivacaine 40 mg and epinephrine 0.1 mg with normal saline to a total volume of 20 mL

Intervention Type PROCEDURE

isolated periarticular multimodal drug injection (PMDI)

periarticular local anesthetic infiltration with 150 mg of ropivacaine, epinephrine 0.3 mg and 30 mg of ketorolac diluted with normal saline to a total volume of 50 mL

Intervention Type PROCEDURE

Other Intervention Names

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PENG + PMDI block Isolated PMDI block

Eligibility Criteria

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Inclusion Criteria

1\. Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective unilateral total hip arthroplasty

Exclusion Criteria

1. Allergy or intolerance to any of the drugs used in the study
2. Hepatic or renal insufficiency
3. Opioid dependency
4. Coagulopathy
5. Pre-existing neurologic or anatomic deficits in the lower extremities
6. Severe psychiatric illness
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kwankyu Park

Role: PRINCIPAL_INVESTIGATOR

Department of orthopaedic surgery, Yonsei University College of Medicine

Locations

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Yonsei University Health System, Severance Hospital

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Kwankyu Park

Role: CONTACT

82-2-2228-2183

Facility Contacts

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Kwankyu Park

Role: primary

82-2-2228-2183

References

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Cho HS, Lee BR, Kwon HM, Park JY, Ham HW, Lee WS, Park KK, Lee TS, Choi YS. Pericapsular Nerve Group Block with Periarticular Injection for Pain Management after Total Hip Arthroplasty: A Randomized Controlled Trial. Yonsei Med J. 2025 Apr;66(4):233-239. doi: 10.3349/ymj.2024.0098.

Reference Type DERIVED
PMID: 40134083 (View on PubMed)

Other Identifiers

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4-2021-1482

Identifier Type: -

Identifier Source: org_study_id

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