Effect of Smoking Cessation on Glycemic Control in Type 2 Diabetics

NCT ID: NCT06687213

Last Updated: 2024-11-13

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 178 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-11-30
• Study Completion Date: 2025-12-31

Brief Summary

The goal of this observational study is to learn about the long-term effects of smoking cessation on glycemic control in type 2 diabetic patients The main question it aims to answer is:

Does smoking cessation lower HbA1c in type 2 diabetics on long term ? The participants will be counseled to cessate smoking and will be followed for 6 months and compared to control who will not cessate smoking .

Detailed Description

Smoking and diabetes are both major public health issues specially in our community. They act synergistically on morbidity and mortality. Diabetic smokers have much higher rates of micro and macrovascular complications. [Carole Clair et al., 2020] Approximately 1.3 billion people worldwide use tobacco, most commonly in the form of tobacco smoking, and more than 7 million people die every year as a result of smoking related conditions [Magdalena Walicka et al.,2022] Exposure to cigarette smoke is associated with vascular damage, endothelial dysfunction, and activation of oxidative stress, inflammatory pathways, coagulation, and fibrinolysis A similar mechanism of endothelial dysfunction is described for people with diabetes. It is therefore not surprising that smoking enhances the combined harmful effects of elevated blood glucose levels, accelerating vascular damage in diabetic patients who smoke The prevalence of current smoking was 45.5% in male patients with type 2 diabetes. The levels of fasting blood glucose and HbA1c increased with number of cigarettes smoked per day compared with non-smokers Smoking and its cessation showed dose- and time-dependent relationship with glycemic control and insulin resistance in patients with type 2 diabetes mellitus. These findings may highlight the importance of smoking cessation in the clinical management of diabetes mellitus.

the effect of smoking and its cessation on glycemic control in diabetic patients has not been fully examined yet.

There is lack of evidence regarding interventions for smoking cessation among individuals with diabetes

Conditions

Smoking Cessation

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

1_Case group 2_control group

1. Case group diabetic smokers which will be counseled to cessate smoking

2. Control group diabetic smokers which will refuse to cessate smoking

Smoking cessation counselling group

Intervention Type: BEHAVIORAL

Case group will be counseled to cessate smoking and will be followed up with HbA1c

Case control group

Case group: diabetic smokers which will cessate smoking Control group: diabetic smokers which will refuse to cessate smoking

No interventions assigned to this group

Interventions

Smoking cessation counselling group

Case group will be counseled to cessate smoking and will be followed up with HbA1c

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Moderate Somking index Having been diagnosed with a type 2 diabetes Being ≥ 35 years old HbA1c > 7

Exclusion Criteria

Type 1 diabetes Drug induced Diabetes mellitus Type 2 diabetes on insulin treatment

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Alhasnaa Mohamed Abdo Rawy

Resident doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Assuit university

Asyut, , Egypt

Countries

Egypt

Central Contacts

Alhasnaa M Rawy, Bachelor of medicine & surgery

Role: CONTACT

alhsnaa.16266104@med.aun.edu.eg

+2001023801711

Facility Contacts

Assuit university

Role: primary

vp_grad@aun.edu.eg

+2088 22080150

Related Links

https://bmjopen.bmj.com/content/10/11/e040117

Related Info

https://pubmed.ncbi.nlm.nih.gov/35800409/

Related Info

https://pubmed.ncbi.nlm.nih.gov/25822499/

Related Info

Other Identifiers

Smoking cessation and HbA1C

Identifier Type: -

Identifier Source: org_study_id