Analysis of Surgical and Oncologic Outcomes After Complete Mesocolic Excision or Non-complete Mesocolic Excision for Right-Sided Colon Cancer
NCT ID: NCT06684223
Last Updated: 2024-11-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
3787 participants
OBSERVATIONAL
2013-01-01
2024-10-31
Brief Summary
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Does a modified D3 approach improve disease-free survival (DFS) in patients with Stage I-III right-sided colon cancer who undergo right-sided colectomy, without increasing surgical complications compared to CME?
Patients with right-sided colon cancer, Stage I-III, who undergo either modified D3 lymphadenectomy or CME as part of their standard treatment, will have their DFS, complications, bleeding volume, number of lymph nodes harvested, and stage distribution compared over a follow-up period. This study ultimately aims to determine the optimal surgical approach for maximizing oncologic outcomes in right-sided colon cancer.
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Detailed Description
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The study aimed to evaluate the efficacy and safety of modified D3 lymphadenectomy compared to Complete Mesocolic Excision (CME) in patients with right-sided colon cancer. Patients with right-sided colon cancer who underwent laparoscopic or robotic right hemicolectomy from 2013 to 2020 were included. Patients were classified into those who received modified D3 lymphadenectomy or CME, and the study assessed disease-free survival (DFS), surgical complications, bleeding volume, lymph node yield, and stage distribution.
Data collection was carried out at multiple tertiary medical centers across the Republic of Korea, ensuring a broad representation of patient demographics and clinical practices. The participating institutions included Asan Medical Center, Korea University Anam Hospital, Severance Hospital, and Kyungpook National University Chilgok Hospital. These centers vary in location and size, enhancing the study's generalizability within the context of right-sided colon cancer management in Korea.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Patients who underwent laparoscopic or robotic right hemicolectomy with modifiedD3 from 2013 to 2020
Patients who underwent laparoscopic or robotic right hemicolectomy with modified D3 lymphadenectomy from 2013 to 2020 in 4 centers
No interventions assigned to this group
Patients who underwent laparoscopic or robotic right hemicolectomy with CME from 2013 to 2020
Patients who underwent laparoscopic or robotic right hemicolectomy with Complete mesocolic excision from 2013 to 2020 in 4 centers
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Patients who received curative right hemicolectomy with lymphadenectomy
Exclusion Criteria
* Hereditary non-polyposis colon cancer (HNPCC)
* Patients with inflammatory bowel disease
* Patients with synchronous malignancies in other organs
* Patients with non-adenocarcinoma histology of colon cancer
ALL
No
Sponsors
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Korea University Anam Hospital
OTHER
Kyungpook National University Chilgok Hospital
OTHER
Severance Hospital
OTHER
Asan Medical Center
OTHER
Responsible Party
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In Ja Park
Professor
Locations
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Asan Medical Center
Seoul, Songpa, South Korea
Countries
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Other Identifiers
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mD3 domestic
Identifier Type: -
Identifier Source: org_study_id
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