Ultrasound Guided Block of Stellate Ganglion Versus Greater Occipital Nerve in Resistant Migraine and Correlation to Calcitonin Gene Related Peptide

NCT ID: NCT06662461

Last Updated: 2024-10-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-02-01

Study Completion Date

2025-03-31

Brief Summary

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To investigate the efficacy of Ultrasound guided Stellate Ganglion block in chronic resistant migraine patients in comparison to Greater Occipital Nerve Block correlating its effect to serum CGRP level.

Detailed Description

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40 Patients diagnosed with Chronic resistant migraine to 2 anti-migraine drugs for 3 months will be evaluated for inclusion and exclusion. Eligible patients with resistance or intolerability to 2 drugs or more will be classified into two groups by using simple randomization methods through Using a computer-generated random number sequence.

Each group will contain 20 patients one group will undergo ultrasound guided bilateral Greater Occipital nerve Block and the other group will undergo ultrasound guided bilateral Stellate Ganglion Block

Conditions

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Migraine

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Ultrasound guided bilateral Greater Occipital nerve Block

Group Type ACTIVE_COMPARATOR

ultrasound guided Greater occipital nerve block

Intervention Type PROCEDURE

Patients will be positioned in a prone position with their neck slightly flexed.

The trapezius , semispinalis, obliqus capitis muscles will be revealed on short-axis view.

A 25- or 21 gauge is used, with puncture point 1-1.5 cm away from the ultrasound probe.

Under the guidance of the ultrasound, GOB will performed by injection using 40 mg triamcinolone and 1ml of 2% lidocaine.

Ultrasound guided bilateral Stellate Ganglion Block

Group Type ACTIVE_COMPARATOR

Ultrasound guided Stellate ganglion block

Intervention Type PROCEDURE

Patients are positioned in a lateral position with their necks slightly hyperextended. Assisted by ultrasound imaging equipment the C7 level is confirmed. The thyroid gland, carotid artery, compressible internal jugular vein, vertebral artery, brachial plexus and the oval-shaped structure of the longus collis muscle are revealed on this short-axis view.

A 25- or 21 gauge is used and the puncture point is 1-1.5 cm away from the ultrasound probe The tip of the needle reach the surface of the longus collis muscle and the 5 o'clock position of the carotid artery. Under the guidance of the ultrasound, SGB is performed by injection using 40 mg triamcinolone and 1ml of 2% lidocaine.

Interventions

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ultrasound guided Greater occipital nerve block

Patients will be positioned in a prone position with their neck slightly flexed.

The trapezius , semispinalis, obliqus capitis muscles will be revealed on short-axis view.

A 25- or 21 gauge is used, with puncture point 1-1.5 cm away from the ultrasound probe.

Under the guidance of the ultrasound, GOB will performed by injection using 40 mg triamcinolone and 1ml of 2% lidocaine.

Intervention Type PROCEDURE

Ultrasound guided Stellate ganglion block

Patients are positioned in a lateral position with their necks slightly hyperextended. Assisted by ultrasound imaging equipment the C7 level is confirmed. The thyroid gland, carotid artery, compressible internal jugular vein, vertebral artery, brachial plexus and the oval-shaped structure of the longus collis muscle are revealed on this short-axis view.

A 25- or 21 gauge is used and the puncture point is 1-1.5 cm away from the ultrasound probe The tip of the needle reach the surface of the longus collis muscle and the 5 o'clock position of the carotid artery. Under the guidance of the ultrasound, SGB is performed by injection using 40 mg triamcinolone and 1ml of 2% lidocaine.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Individuals diagnosed with chronic resistant migraine after using or intolerability to 2 or more of anti-migraine drugs for at least 3 months

Exclusion Criteria

* Patients with a space-occupying lesion.
* Coagulation disorders.
* Systemic or local infection and drug allergies.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ahmed Mohamed ElSadek

UNKNOWN

Sponsor Role collaborator

Sherien Mohamed Farag

UNKNOWN

Sponsor Role collaborator

Noha Lotfy Soliman

UNKNOWN

Sponsor Role collaborator

Mohamed Amir Tork

UNKNOWN

Sponsor Role collaborator

Ahmed Mohamed Abdelfattah Sharawy

UNKNOWN

Sponsor Role collaborator

Ain Shams University

OTHER

Sponsor Role lead

Responsible Party

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Mai Fathy Ahmed Fahmy

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ain Shams University Hospital

Cairo, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Mai Fathy Ass.Prof.Mai Fathy

Role: CONTACT

+2001023868846

Facility Contacts

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Ass.Prof.Mai Fathy

Role: primary

+2001023868846

Other Identifiers

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FMASU MD14/2024

Identifier Type: -

Identifier Source: org_study_id

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