Greater Occipital and Supraorbital Nerve Blockade in Migraine Patients

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

103 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-09-01

Study Completion Date

2016-06-01

Brief Summary

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The investigators aimed to evaluate the efficacy of greater occipital nerve and supraorbital nerve blockade with local anesthetics for the preventive treatment of migraine without aura.

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Detailed Description

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A mixture of 1 ml 2% lidocaine and 0.9% 1 ml saline was injected bilaterally to GON and SON in the blockade patients. Placebo patients received 2 ml 0.9% saline in the same way. Patients were blinded to kind of injection.

Conditions

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Migraine Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Blockade Group

Lidocaine injections. Procedure. Grater occipital nerve and supraorbital nerve were blocked with %2 lidocaine. These injections were repeated weekly for three weeks. After treatment was completed, patients were followed up for 2 months at the polyclinic to assess the clinical response.

Group Type ACTIVE_COMPARATOR

Lidocaine injections

Intervention Type PROCEDURE

Lidocaine injections. A mixture of 1 ml 2% lidocaine and 0.9% 1 ml saline was injected bilaterally to greater occipital nerve and supraorbital nerve in the blockade patients.

Placebo Group

Saline injections. Procedure. Grater occipital nerve and supraorbital nerve were injected with saline.These injections were repeated weekly for three weeks. After treatment was completed, patients were followed up for 2 months at the polyclinic to assess the clinical response.

Group Type PLACEBO_COMPARATOR

Saline injections

Intervention Type PROCEDURE

Saline injections. Patients received 2 ml 0.9% saline in bilaterally to greater occipital nerve and supraorbital nerve

Interventions

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Lidocaine injections

Lidocaine injections. A mixture of 1 ml 2% lidocaine and 0.9% 1 ml saline was injected bilaterally to greater occipital nerve and supraorbital nerve in the blockade patients.

Intervention Type PROCEDURE

Saline injections

Saline injections. Patients received 2 ml 0.9% saline in bilaterally to greater occipital nerve and supraorbital nerve

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Lack of benefits 1 year from preventive treatment or intolerance to their treatments.
* 18 ≥ years old
* Migraine without aura for more than 1 year, minimum of two or more migraine attacks per month.

Exclusion Criteria

* Patients with any chronic illness, medication overuse headache, a history of cranial and cervical surgery
* Allergies to local anesthetics
* Hemorrhagic diathesis
* Alcohol or drug abuse

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No