The Effects of Dexmedetomidine on Postoperative Cognitive Function in Open Heart Surgery

NCT ID: NCT06655025

Last Updated: 2024-10-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-08

Study Completion Date

2025-10-08

Brief Summary

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To assess the impact of Dexmedetomidine on postoperative cognitive function and serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgery

Detailed Description

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Conditions

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Open Heart Sugery Neuronal Damage

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Group B (Dexmedetomidine)

Dexmedetomidine infusion

Group Type ACTIVE_COMPARATOR

Dexmedetomidine

Intervention Type DRUG

Dexmedetomidine infusion during open heart surgery

Group A (control)

normal saline infusion

Group Type PLACEBO_COMPARATOR

Dexmedetomidine

Intervention Type DRUG

Dexmedetomidine infusion during open heart surgery

Interventions

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Dexmedetomidine

Dexmedetomidine infusion during open heart surgery

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients of both sexes undergoing elective open-heart surgery

Exclusion Criteria

* Patients with a history of neurological disorders, severe renal or liver dysfunction, or contraindications to Dexmedetomidine as in patients with known QT prolongation, a history of other arrhythmias, symptomatic bradycardia, hypokalemia, or hypomagnesemia, and in patients receiving other drugs known to prolong the QT interval.

Patients with cognitive impairment, mental and psychological illness and chronic alcoholics, drug addicts, abuse of psychotropic substances, illiterate education
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Salaheldin Ahmed Abdelziz

specialist

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Sohag University

Sohag, , Egypt

Site Status RECRUITING

Countries

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Egypt

Facility Contacts

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Salah Eldin Ahmed Abdeluaziz, master

Role: primary

01001308006

Other Identifiers

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Soh-Med-15-10-1MD

Identifier Type: -

Identifier Source: org_study_id

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