Brain Health in Midlife

NCT ID: NCT06640842

Last Updated: 2025-06-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

24 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-23

Study Completion Date

2025-06-13

Brief Summary

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The purpose of this study is to learn if hypertensive disorders during pregnancy affects brain health in midlife.

Detailed Description

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Conditions

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Brain Health Gestational Hypertension Alzheimer Disease Dementia Cardiovascular Diseases Pregnancy Related Pre-Eclampsia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Hypertensive disorder of pregnancy

Women who were diagnosed with a hypertensive disorder of pregnancy during the ADORE study participation.

A combination of various test and biomarkers will be completed to understand the effect of hypertensive disorders of pregnancy in brain health in midlife.

Intervention Type DIAGNOSTIC_TEST

Participants will be asked to complete a blood draw, 5-lead ECG, MRI, a series of cognitive assessments, dietary assessments, monitor sleep and physical activity and DXA scan.

Healthy pregnancy

Women who participated in the ADORE study and had a healthy pregnancy during their participation.

A combination of various test and biomarkers will be completed to understand the effect of hypertensive disorders of pregnancy in brain health in midlife.

Intervention Type DIAGNOSTIC_TEST

Participants will be asked to complete a blood draw, 5-lead ECG, MRI, a series of cognitive assessments, dietary assessments, monitor sleep and physical activity and DXA scan.

Interventions

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A combination of various test and biomarkers will be completed to understand the effect of hypertensive disorders of pregnancy in brain health in midlife.

Participants will be asked to complete a blood draw, 5-lead ECG, MRI, a series of cognitive assessments, dietary assessments, monitor sleep and physical activity and DXA scan.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Participated in the ADORE trial ( R01 HD083292)

Exclusion Criteria

* History of seizures or Epilepsy
* Pregnant at screening
* Ineligible to complete MRI due to metal in the body
Minimum Eligible Age

18 Years

Maximum Eligible Age

54 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Aging (NIA)

NIH

Sponsor Role collaborator

University of Kansas Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Holly R Hull, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Kansas Medical Center

Locations

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The University of Kansas Medical Center

Kansas City, Kansas, United States

Site Status

Countries

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United States

Other Identifiers

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P30AG072973

Identifier Type: NIH

Identifier Source: secondary_id

View Link

STUDY00160885

Identifier Type: -

Identifier Source: org_study_id

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